Results 11 to 20 of about 41,018 (241)

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein [PDF]

IUCrJ, 2019
Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor.
Alice Dawson, Paul Trumper, Juliana Oliveira de Souza, Holly Parker, Mathew J. Jones, Tim G. Hales, William N. Hunter   +6 more
doaj   +4 more sources

Characterization of optogenetically activated inhibitory inputs onto cholinergic motor neurons in the spinal dorsolateral nucleus. [PDF]

Physiol Rep
Abstract Inhibitory control of external urethral sphincter motor neurons (EUS‐MNs) in the spinal dorsolateral nucleus (DLN), which corresponds to a portion of Onuf's nucleus in humans, is essential for normal micturition by inducing EUS relaxation during voiding; yet synaptic mechanisms remain poorly characterized.
Kamijo TC, Karnup S, Matsuoka K, Kimura S, Miyazato M, Daugherty SL, Beckel JM, Yoshimura N.   +7 more
europepmc   +2 more sources

A rare case report of Strychnos nux-vomica poisoning with bradycardia

Journal of Family Medicine and Primary Care, 2017
Strychnine poisoning is a rare method of deliberate self-harm in adults. Poisoning with strychnine leaves is a rare form of strychnine poisoning, as the usual plant parts used are nuts, bark, and seeds.
Lesley Ponraj, Ajay Kumar Mishra, Maria Koshy, Ronald Albert Benton Carey   +3 more
doaj   +1 more source

The functional role of GABA and glycine in monaural and binaural processing in the inferior colliculus of horseshoe bats [PDF]

, 1992
The functional role of GABA and glycine in monaural and binaural signal analysis was studied in single unit recordings from the central nucleus of the inferior colliculus (IC) of horseshoe bats (Rhinolophus rouxi) employing microiontophoresis of the ...
Grothe, Benedikt, Habbicht, Hartmann, Kössl, Manfred, Vater, Marianne   +3 more
core   +1 more source

Interaural time difference processing in the mammalian medial superior olive [PDF]

, 2008
The dominant cue for localization of low-frequency sounds are microsecond differences in the time-of-arrival of sounds at the two ears [interaural time difference (ITD)].
Behrend, Oliver, Brand, Antje, Grothe, Benedikt, Pecka, Michael   +3 more
core   +1 more source

Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina. [PDF]

, 2014
This paper examines the role of inhibition in generating the receptive-field properties of local edge detector (LED) ganglion cells in the rabbit retina. We confirm that the feed-forward inhibition is largely glycinergic but, contrary to a recent report,
Buldyrev, Ilya, Sivyer, Benjamin, Taylor, Rowland, Van Wyk, Michiel, Vaney, David, Venkataramani, Sowmya   +5 more
core   +2 more sources

Annexin A2 Causes Motor Incoordination via Muscle-Cerebellum Axis in Sarcopenia. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Sarcopenia is a prevalent age‐related disorder characterized by progressive muscle atrophy. Impaired balance is one of its most critical clinical consequences, often leading to falling and even bone fractures. As the cerebellum plays a central role in regulating motor coordination, elucidating the molecular mechanisms underlying ...
Jiao X, Wang Z, Chang H, Li Y, Wang B, Shao X, Zhang Y, Lin Y, Jia X, Zhou X, Li W, Luo D, Deng T, Lin X, Xu C, Gan Y, Gu D.   +16 more
europepmc   +2 more sources

The envenomation of general physiology throughout the last century. [PDF]

, 2017
Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
core   +1 more source

Moles and Mole Control on British Farms, Amenities and Gardens after Strychnine Withdrawal

Animals, 2016
Moles are considered pests in Britain, but this issue has been little studied. Lower welfare standards have been tolerated for moles than for most other managed wild mammal species, as use of both the controversial poison, strychnine, and unregulated ...
Sandra E. Baker, Stephen A. Ellwood, Paul J. Johnson, David W. Macdonald   +3 more
doaj   +1 more source

Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]

, 2007
Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas, Chang, Cymes, Cymes, Dahan, England, Gandhi, Grosman, Han, Hawthorne, Hawthorne, Hemmings, Kondratskaya, Kondratskaya, Law, Lee, Lewis, Lobo, Lynch, Lynch, Lynch, Miyazawa, Muroi, O'Shea, Paas, Rajendra, Shan, Unwin, Unwin, Webb, Wilson   +30 more
core   +3 more sources