Results 61 to 70 of about 41,018 (241)

Thiophenderivate als vielseitige Vorstufen für die Synthese von (Hetero)aromaten und Naturstoffen

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Verborgen, aber leistungsstark: Thiophene und ihre gesättigten Analoga haben sich als vielseitige C4‐Bausteine erwiesen, die sich effektiv in der Naturstoffsynthese sowie beim Aufbau funktionalisierter (Hetero)aromaten einsetzen lassen. Dieser Minireview soll einen Überblick über Strategien zur Anwendung dieser schwefelhaltigen heterozyklischen ...
Anna Keimer, Franz‐Lucas Haut
wiley   +1 more source

Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Important Poisonous Plants in Tibetan Ethnomedicine

Toxins, 2015
Tibetan ethnomedicine is famous worldwide, both for its high effectiveness and unique cultural background. Many poisonous plants have been widely used to treat disorders in the Tibetan medicinal system.
Lijuan Ma, Ronghui Gu, Li Tang, Ze-E Chen, Rong Di, Chunlin Long   +5 more
doaj   +1 more source

Thiophene Derivatives as Versatile Precursors for (Hetero)Arene and Natural Product Synthesis

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Hidden but Powerful: Thiophenes and their saturated analogues have been demonstrated to be versatile C4‐building blocks that can be rapidly applied to natural product synthesis and the construction of functionalized (hetero)arenes. This minireview aims to provide a concise overview of the strategies and implementations of these sulfur‐containing ...
Anna Keimer, Franz‐Lucas Haut
wiley   +1 more source

Impaired WNT3/IGF‐1 Signaling in Dorsal Dentate Gyrus Contributes to Chronic Pain‐Related Cognitive Impairment

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
Schematic diagram depicting the mechanism of SNI‐induced comorbidity of pain and cognition decline. SNI increased TNFα release in the dorsal DG (1); TNFα trigger a “double hit” to dorsal DG homeostasis: On the one hand, TNFα induced IGF‐1 resistance in granule neuron.
Yajie An, Ying Wu, Xiangyong Li, Taihe Zhou, Heming Liu, Yao Xiao, Wenyu Lai, Yuxin Qiu, Xuhong Wei   +8 more
wiley   +1 more source

Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa armigera.

PLoS Genetics, 2022
Many plant secondary substances are feeding deterrents for insects and play a key role in the selection of host plants. The taste sensilla of phytophagous insects contain gustatory sensory neurons sensitive to deterrents but the molecular basis of ...
Yan Chen, Pei-Chao Wang, Shuai-Shuai Zhang, Jun Yang, Guo-Cheng Li, Ling-Qiao Huang, Chen-Zhu Wang   +6 more
doaj   +1 more source

Overview of acute Chinese medicine poisoning in Hong Kong

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 6, December 2025.
Abstract Background Chinese medicine (CM) poisoning is relatively rare in Hong Kong. According to the Department of Health, only 17 cases of self‐medicated Traditional Chinese Medicine (TCM)‐related poisoning were reported between 2019 and 2021—an average of approximately 5.7 cases per year.
Siu Kan Law, Yanping Wang, Xiao Xiao Wu
wiley   +1 more source

Optimization of an LC–MS/MS analytical method for strychnine in livestock and fishery products

Applied Biological Chemistry
Strychnine, an alkaloid recognized for its antagonist effects on glycine and acetylcholine receptors, is highly toxic and banned in several countries. It is also set to restricted in Republic of Korea from 2024, creating a need for a quantitative test ...
Jin Ha Sim, Hyesu Lee, Ji Young Kim, So–Ra Park, Gui–Hyun Jang, Miok Eom   +5 more
doaj   +1 more source

Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway

Journal of Neuroinflammation, 2020
Background Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations
Yaiza M. Arenas, Andrea Cabrera-Pastor, Nora Juciute, Eloy Mora-Navarro, Vicente Felipo   +4 more
doaj   +1 more source

Evaluation of glycine treatment for reducing alcohol craving and self‐administration in individuals with alcohol use disorder: A human laboratory trial

Alcohol, Clinical and Experimental Research, Volume 49, Issue 12, Page 2836-2854, December 2025.
This RCT evaluated whether the glycine receptor (GlyR) agonist glycine reduces craving and alcohol intake in individuals with AUD. Despite a preclinical rationale for targeting the GlyR, these parameters were not reduced. Interestingly, glycine weakened the link between alcohol‐induced craving and self‐administration, and baseline glycine levels were ...
Yasmin Olsson, Helga Lidö, Mia Ericson, Bo Söderpalm   +3 more
wiley   +1 more source