Results 81 to 90 of about 37,910 (211)
Optimization of an LC–MS/MS analytical method for strychnine in livestock and fishery products
Applied Biological ChemistryStrychnine, an alkaloid recognized for its antagonist effects on glycine and acetylcholine receptors, is highly toxic and banned in several countries. It is also set to restricted in Republic of Korea from 2024, creating a need for a quantitative test ...
Jin Ha Sim +5 more
doaj +1 more source
Journal of Neuroinflammation, 2020 Background Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway. Hyperammonemia also increases glycinergic neurotransmission. These alterations
Yaiza M. Arenas +4 more
doaj +1 more source
Synaptic Inhibition Influences the Temporal Coding Properties of Medial Superior Olivary Neurons. An in vitro Study [PDF]
, 1994 The medial superior olive (MSO) functions as a coincidence detector for interaural time and phase differences by integrating excitatory synaptic inputs.
Grothe, Benedikt, Sanes, Dan H.
core +1 more source
The Journal of Physiology, Volume 604, Issue 7, Page 3077-3093, 1 April 2026.Abstract figure legend A, schematic illustration of the ventral aspect of an ex vivo preparation of the entire CNS from a neonatal rat subjected to a calibrated thoracic impact. The trauma induced a large depolarising injury potential (DIP, black trace) recorded from the L5 ventral root (VRrL5), which was markedly reduced by transient receptor ...
Atiyeh Mohammadshirazi +5 more
wiley +1 more source
Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits. [PDF]
PLoS ONE, 2012 BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease.
Florian Wegner +7 more
doaj +1 more source
Biomedical Chromatography, Volume 40, Issue 3, March 2026.ABSTRACT Veratrum L. species have been used in traditional medicine for centuries due to their bioactive properties, yet they also contain toxic steroid alkaloids that pose potential health risks when present in herbal preparations. Reliable analytical approaches are therefore essential to ensure product safety, protect consumer health and assess ...
Julia Siegle, Jörg Pietsch
wiley +1 more source
Indeed, No Need for HMPA! A DFT Study Comparing the Lewis Basicity of Phosphoric Acid Triamides
ChemistryEurope, Volume 4, Issue 3, March 2026.High‐level density functional theory calculations of the interactions of protons, lithium cations, and samarium(II) and samarium(III) species with a series of Lewis bases reveal that TPPA and HAPO‐2 are stronger donor compounds than HMPA. Therefore, they should by excellent substitutes of carcinogenic and mutagenic HMPA in many reactions.
Luca Steiner +3 more
wiley +1 more source
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]
, 2012 Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke +3 more
core +1 more source
Flow Compensation Recovers Sensitivity Lost to Convection in Gradient‐Enhanced TOCSY NMR Experiments
Chemistry–Methods, Volume 6, Issue 3, March 2026.Gradient‐enhanced TOCSY techniques are an essential tool in the NMR spectroscopist's toolkit. However, in the presence of convection, signal intensities can be severely diminished, an issue that is particularly common when using cryoprobes. Here, we present an easily implemented TOCSY experiment that reverses signal loss due to convection and ...
Elsa Caytan +4 more
wiley +1 more source