Results 171 to 180 of about 534,772 (185)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Comparison of academic performance of medical students previously and non-previously graduated from other college courses in a PBL hybrid curriculum. [PDF]

open access: yesBMC Med Educ
Couto LB   +10 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

Meaningful youth engagement in sexual and reproductive health and rights decision making

open access: yesThe Lancet Global Health
Klaudia Szymuś   +7 more
doaj   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

open access: yesFEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns   +2 more
wiley   +1 more source

The Student's Health Brigades in Latin America and their future prospect

open access: yesActa Médica del Centro, 2010
Lesly Alberto Somarriba Ordóñez
doaj  

Rare disease education in medical schools: patient-centered and innovative strategies. [PDF]

open access: yesOrphanet J Rare Dis
Huynh S   +6 more
europepmc   +1 more source

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