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The sub-chronic toxicity in rats of isoparaffinic solvents
Regulatory Toxicology and Pharmacology, 2013Results from a 13-week inhalation study in rats on a C10-C12 isoparaffinic solvent are compared to the results of repeated inhalation and oral toxicity studies of four other isoparaffinic hydrocarbon solvents. Statistically significant findings which were consistent across all studies included: nephropathy and small but significant changes in ...
Juan-Carlos, Carrillo +5 more
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The sub-chronic toxicity of a naphthenic hydrocarbon solvent in rats
Regulatory Toxicology and Pharmacology, 2018Cycloalkanes/naphthenes are constituents of complex hydrocarbon solvents, and hence an understanding of their toxicological profile is critical to establish safe limits for occupational exposures to these solvents. Although naphthenes are structurally related to and share a common metabolic fate with the straight and branched chain analogues, some ...
Juan-Carlos, Carrillo +3 more
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Sub-chronic toxicity of methyl benzimidazole carbamate in rats
Bulletin of Environmental Contamination and Toxicology, 1987Methyl benzimidazole carbamate (MBC) is a broad spectrum systemic fungicide effectively used against a wide variety of pests of vegetable crops and fruit orchards. On seed treatment MBC was found to be actively absorbed by the seedlings and transported to aerial parts.
A, Janardhan, A B, Rao, P, Sisodia
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The sub-chronic toxicity of regular White Spirit in rats
Regulatory Toxicology and Pharmacology, 2014Hydrocarbon solvents are mostly complex substances (UVCB) with carbon numbers in the range of approximately C5-C20. One of the most common types is a C9-C14 aliphatic solvent containing approximately 20% aromatics and commonly known as White Spirit in Europe and mineral spirits in the US.
Juan-Carlos, Carrillo +2 more
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Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
Toxicology, 2003Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating wildlife. This study investigated the hypotheses that early hepatocellular peroxisomal proliferation and hepatic cellular proliferation are factors in chronic liver response ...
Andrew M, Seacat +6 more
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Acute and sub-chronic toxicity studies of honokiol microemulsion
Regulatory Toxicology and Pharmacology, 2015The purpose of this study was to investigate the acute and sub-chronic toxicity of honokiol microemulsion. In the acute toxicity tests, the mice were intravenously injected graded doses of honokiol microemulsion and were observed for toxic symptoms and mortality daily for 14 days.
Qianqian, Zhang +7 more
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Toxicological Research, 2021
Extracts of Hordeum vulgare and Chrysanthemum zawadskii, two traditional herbal medicines, have long been used to treat women's diseases. Our previous studies have confirmed that these extracts could help relieve the symptoms of premenstrual syndrome by inhibiting prolactin release. A mixture of these natural products was named Lomens-P0. In this study,
Yong Joon Jeong +5 more
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Extracts of Hordeum vulgare and Chrysanthemum zawadskii, two traditional herbal medicines, have long been used to treat women's diseases. Our previous studies have confirmed that these extracts could help relieve the symptoms of premenstrual syndrome by inhibiting prolactin release. A mixture of these natural products was named Lomens-P0. In this study,
Yong Joon Jeong +5 more
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Acute and sub-chronic toxicity study of diaveridine in Wistar rats
Regulatory Toxicology and Pharmacology, 2015Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its toxicity. To provide detailed toxicity with a wide spectrum of doses for diaveridine, acute and sub-chronic toxicity studies were conducted.
Xu Wang, Yulian Wang, Guyue Cheng
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Acute and (sub)chronic toxicity of the neonicotinoid imidacloprid on Chironomus riparius
Chemosphere, 2018Impacts of neonicotinoids on non-target insects, including aquatic species, may significantly influence ecosystem structure and functioning. The present study investigated the sensitivity of Chironomus riparius to imidacloprid exposures during 24-h, 10- and 28-days by assessing larval survival, growth, emergence and oxidative stress-related parameters.
Naveen Njattuvetty Chandran +4 more
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Sub-chronic toxicity of Gyejibokryeong-hwan in Sprague-Dawley rats
Journal of Ethnopharmacology, 2018Traditional herbal formula Gyejibokryeong-hwan (GJBRH; Guizhifuling-wan, Keishibukuryo-gan) consisting five medicinal herbs has been used to treat uterine disorders, gynecological diseases and blood stasis syndrome in Asia.We evaluated the safety of GJBRH in Crl:CD Sprague-Dawley (SD) rats over a period of 13 weeks.To confirm the stability of the ...
Seong Eun, Jin +5 more
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