Results 151 to 160 of about 780 (181)

Acute and sub-chronic toxicity of four cytostatic drugs in zebrafish

Environmental Science and Pollution Research, 2015
The acute and sub-chronic effects of four cytostatic drugs-5-fluorouracil (5-FU), cisplatin (CisPt), etoposide (ET) and imatinib mesylate (IM)-on zebrafish (Danio rerio) were investigated. Acute tests were carried out in a static system in accordance with the OECD guideline 203 for adult fish and the draft guideline for fish embryos (FET test) in order
Róbert Kovács, Katalin Bakos, Béla Urbányi, Judit Kövesi, Gyöngyi Gazsi, Andrea Csepeli, Ádám János Appl, Dóra Bencsik, Zsolt Csenki, Ákos Horváth   +9 more
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Pathology of sub-chronic cadmium and chlorpyrifos toxicity in broilers

Indian Journal of Veterinary Pathology, 2016
The present study was conducted to evaluate the toxic effects of cadmium and chlorpyrifos and their interaction on liver and kidney of broiler chicken. Twenty four birds were divided into four groups. Group-I was kept as control. Group-II, III and IV birds were administered with cadmium (50 mg/L in drinking water), chlorpyrifos (4 mg/kg body weight ...
R. Singh, A.K. Srivastava, N.K. Gangwar, D.K. Giri, Renu Singh, Rahul Kumar   +5 more
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Sub-chronic oral toxicity of acetamiprid in Wistar rats

Toxicological & Environmental Chemistry, 2015
Acetamiprid is a neoncotinoid insecticide that acts as an agonist to the nicotinic acetylcholine receptor used as insecticide in crops and to control fleas on dogs and cats. The objectives of this study are (1) to evaluate the sub-chronic toxicity of orally administered acetamiprid, (2) to estimate the tissue residue levels and (3) to assess the ...
R.K. Shakthi Devan, Akhilesh Mishra, P.C. Prabu, T.K. Mandal, S. Panchapakesan   +4 more
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Toxicity assessment due to sub-chronic exposure to individual and mixtures of four toxic heavy metals

Journal of Hazardous Materials, 2015
Humans are exposed to a cocktail of heavy metal toxicants in the environment. Though heavy metals are deleterious, there is a paucity of information on toxicity of low dose mixtures. In this study, lead (Pb) (0.01mg/L), mercury (Hg) (0.001mg/L), cadmium (Cd) (0.005mg/L) and arsenic (As) (0.01mg/L) were administered individually and as mixtures to 10 ...
Samuel J, Cobbina, Yao, Chen, Zhaoxiang, Zhou, Xueshan, Wu, Ting, Zhao, Zhen, Zhang, Weiwei, Feng, Wei, Wang, Qian, Li, Xiangyang, Wu, Liuqing, Yang   +10 more
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Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents

Journal of Ethnopharmacology, 2009
Steroidal saponins from Dioscorea zingiberensis are widely used in China for curing cardiovascular diseases. However, there was little toxicological information available on them.The study evaluated potential toxicity of the steroidal saponins and analyzed the metabolites in rats.For the acute study, the steroidal saponins were administered to kunming ...
Yuan, Qin, Xiaohua, Wu, Wen, Huang, Guohua, Gong, Dan, Li, Yang, He, Yinlan, Zhao   +6 more
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Evaluation of the sub-chronic toxicity of a standardized flavonoid extract of safflower in rats

Regulatory Toxicology and Pharmacology, 2017
Carthamus tinctorius L., or safflower, is an annual herbaceous crop belonging to the family Asteraceae, which is cultivated throughout China and used as a traditional Chinese medicine. Our previous study revealed anti-Parkinson's disease effects of an isolated standardized safflower flavonoid extract (SAFE). The purpose of this study is to evaluate the
Zhilin, Zhang, Runzhe, Liu, Xiaoping, Pu, Yi, Sun, Xin, Zhao   +4 more
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The sub-chronic oral toxicity of 1,3,5-trimethylbenzene in Sprague–Dawley rats

Regulatory Toxicology and Pharmacology, 2014
The systemic toxicity of a trimethylbenzene isomer and constituent of C9 aromatic solvents (1,3,5-trimethylbenzene, 135-TMB) was studied in Sprague-Dawley rats following a 90-day oral gavage exposure to 0, 50, 200 and 600 mg/kg/day. No statistically significant effects on body weight, body weight gain or food consumption were observed at study ...
David, Adenuga, Juan-Carlos, Carrillo, Richard H, Mckee   +2 more
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Acute and sub-chronic oral toxicity studies of erythritol in Beagle dogs

Food and Chemical Toxicology, 2017
Polyols, also known as sugar alcohols, are widely used in the formulation of tooth-friendly and reduced-calorie foods. Considering the significant health benefits of polyols in products formulated for human use, there is increased interest in evaluating potential uses in companion animal applications.
Alex K, Eapen, Peter, de Cock, Christine M, Crincoli, Charlotte, Means, Tina, Wismer, Christopher, Pappas   +5 more
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Acute and sub-chronic toxicity studies of the extract of Thunberg Fritillary Bulb

Regulatory Toxicology and Pharmacology, 2014
The aim of this study was to investigate the acute and sub-chronic toxicity of extract of Thunberg Fritillary Bulb. For the acute toxicity tests, graded doses of the extract were administered orally to mice. The animals were observed for toxic symptoms and mortality daily for 14days.
Zehui, Li, Yuan, Qiao, Jianguo, Li, Chao, An, Kaiwen, Hu, Minke, Tang   +5 more
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Sub-Chronic Toxicity of Senilia senilis Hepatopancreas in Albino Wistar Mice

Bulletin of Environmental Contamination and Toxicology, 2010
This study investigates the sub-chronic effects of shellfish possibly contaminated by algal toxins in albino Wistar mice. Following in-feed treatment with hepatopancreas, there were significant (p < 0.05) differences in packed cell volume, haemoglobin concentration, red blood cell count, lymphocyte count and alanine aminotransferase between the ...
Okechukwu O, Igboeli, Isaac U, Asuzu
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