Results 101 to 110 of about 3,864,827 (278)
ACUTE AND SUB CHRONIC TOXICITY STUDIES OF PURIFIED WITHANIA SOMNIFERA EXTRACT IN RATS [PDF]
, 2018 Objective: The objective of the present study was to evaluate the acute and sub-chronic (90 d; repeated dose) toxicity of Withania somnifera (ashwagandha) extract in rats.Methods: The acute toxicity was evaluated as per OECD (Organisation for Economic Co-
Jacob, Sherina +5 more
core +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
Advanced Healthcare Materials, EarlyView.LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
Sub-chronic toxicity of chemically synthesized CuO-NPs in albino mice
BiomarkersObjectives: The current study explores the synthesis, characterization and toxicity of copper oxides (CuO-NPs) in albino mice. Methods: NPs were synthesized and albino mice were exposed to these nps orally for 30 days. Results: The nanoparticles exhibited a porous, rough-surfaced, spherical morphology; XRD confirmed their crystallinity, while FTIR ...
Muhammad Waseem Aslam +5 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Advances in cell sources, bioengineering, and manufacturing are reshaping the design of skin substitutes. This review highlights emerging strategies driving skin tissue engineering and discusses their potential to enable safer, reproducible, and clinically accessible skin substitutes for regenerative medicine.
Gilles Lemaître +7 more
wiley +1 more source
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
Bulletin of Pharmaceutical Sciences. Assiut UniversityEphedra nebrodensis Tineo is a rare medicinal plant in eastern Algeria. To the best knowledge, no research has evaluated the safety of aqueous extract from E. nebrodensis Tineo.
Meriem Hamoudi +7 more
doaj +1 more source
Research progress on toxic effect of aflatoxins B1 in broiler chickens
Siliao yanjiu, 2023 Aflatoxin B1 (AFB1) is the most powerful carcinogen and highly toxic mycotoxin known in nature. AFB1 can contaminate the broiler diet and limit the development of broiler breeding in China. At present, the toxicity of AFB1 to broilers is mainly reflected
LI Yu-fang +6 more
doaj
A k-NN algorithm for predicting oral sub-chronic toxicity in the rat
ALTEX, 2014 Repeated dose toxicity is of the utmost importance to characterize the toxicological profile of a chemical after repeated administration. Its evaluation refers to the Lowest-Observed-(Adverse)-Effect-Level (LO(A)EL) explicitly requested in several regulatory contexts, such as REACH and EC Regulation 1223/2009 on cosmetic products.
GADALETA, DOMENICO +6 more
openaire +4 more sources
Nitrofurantoin-Induced Pulmonary Toxicity: Mechanisms, Diagnosis, and Management
Nitrofurantoin, a commonly prescribed antibiotic for urinary tract infections, has been associated with rare but potentially serious pulmonary toxicity, which can present in acute, subacute, or chronic forms.
Shahab Ahmadzadeh +7 more
core +1 more source
Advanced Materials, EarlyView.Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song +14 more
wiley +1 more source