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Acute and sub-chronic toxicity study of diaveridine in Wistar rats

Regulatory Toxicology and Pharmacology, 2015
Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its toxicity. To provide detailed toxicity with a wide spectrum of doses for diaveridine, acute and sub-chronic toxicity studies were conducted.
Xu Wang, Yulian Wang, Guyue Cheng
exaly   +3 more sources

Evaluation of the acute, sub-chronic and chronic oral toxicity, genetic toxicity, and safety of a Lomens-P0

Toxicological Research, 2021
Extracts of Hordeum vulgare and Chrysanthemum zawadskii, two traditional herbal medicines, have long been used to treat women's diseases. Our previous studies have confirmed that these extracts could help relieve the symptoms of premenstrual syndrome by inhibiting prolactin release. A mixture of these natural products was named Lomens-P0. In this study,
Yong Joon Jeong   +5 more
openaire   +2 more sources

Dynamics of microcystins-LR and -RR in the phytoplanktivorous silver carp in a sub-chronic toxicity experiment

open access: yesEnvironmental Pollution, 2004
A sub-chronic toxicity experiment was conducted to examine tissue distribution and depuration of two microcystins (microcystin-LR and microcystin -RR) in the phytoplanktivorous filter-feeding silver carp during a course of 80 days. Two large tanks (A, B)
Liqiang Xie
exaly   +1 more source

The sub-chronic toxicity in rats of isoparaffinic solvents

Regulatory Toxicology and Pharmacology, 2013
Results from a 13-week inhalation study in rats on a C10-C12 isoparaffinic solvent are compared to the results of repeated inhalation and oral toxicity studies of four other isoparaffinic hydrocarbon solvents. Statistically significant findings which were consistent across all studies included: nephropathy and small but significant changes in ...
Juan-Carlos, Carrillo   +5 more
openaire   +2 more sources

The LD50and Chronic Toxicity of Reactor Terphenyls

Archives of Environmental Health: An International Journal, 1973
Acute ingestion of reactor coolant terphenyls (HB-40) revealed LD50 values of 17,500 mg/kg rat and 12,500 mg/kg mouse for nonirradiated coolant and 6,000 mg/kg mouse or rat for irradiated coolant. Chronic ingestion of the mixtures by mice produced mitochondrial changes in epithelial cells of proximal tubules, and at high doses these cells became ...
I Y, Adamson, J L, Weeks
openaire   +2 more sources

Evaluation of acute and sub-chronic oral toxicities of Neoneaster in rats

Journal of Ethnopharmacology, 2023
Jaundice is a condition caused by the elevation of bilirubin level in the blood. Due to the neurological and neurodevelopmental sequalae of jaundice in newborns, the high cost of the treatment, and the side effects of the currently used therapies, novel therapeutically approaches are needed.
Nima Aramipour   +6 more
openaire   +2 more sources

The sub-chronic toxicity of a naphthenic hydrocarbon solvent in rats

Regulatory Toxicology and Pharmacology, 2018
Cycloalkanes/naphthenes are constituents of complex hydrocarbon solvents, and hence an understanding of their toxicological profile is critical to establish safe limits for occupational exposures to these solvents. Although naphthenes are structurally related to and share a common metabolic fate with the straight and branched chain analogues, some ...
Juan-Carlos, Carrillo   +3 more
openaire   +2 more sources

Sub-chronic toxicity of methyl benzimidazole carbamate in rats

Bulletin of Environmental Contamination and Toxicology, 1987
Methyl benzimidazole carbamate (MBC) is a broad spectrum systemic fungicide effectively used against a wide variety of pests of vegetable crops and fruit orchards. On seed treatment MBC was found to be actively absorbed by the seedlings and transported to aerial parts.
A, Janardhan, A B, Rao, P, Sisodia
openaire   +2 more sources

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