Results 71 to 80 of about 2,097,328 (330)

P440Targeting subcellular GRK2 localization [PDF]

Cardiovascular Research, 2014
GRK2 is a kinase involved in the regulation of G protein coupled receptor signaling and in particular phosphorylates beta adrenergic receptors at plasma membrane leading to desensitization. In animal and human models of heart failure, its increased level and activity are associated with a worse prognosis.
A Anastasio, AL Carillo, M Ciccareli, B Trimarco, G Iaccarino, D Sorriento   +5 more
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress [PDF]

, 2013
Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA.
Argüelles-Castilla, Sandro, Ayala, Antonio, Camandola, Simonetta, Cutler, Roy G., Hutchison, Emmette R., Mattson, Mark P.   +5 more
core   +1 more source

Plant-mSubP: a computational framework for the prediction of single- and multi-target protein subcellular localization using integrated machine-learning approaches

AoB Plants, 2019
The subcellular localization of proteins is very important for characterizing its function in a cell. Accurate prediction of the subcellular locations in computational paradigm has been an active area of interest.
S. Sahu, Cristian D. Loaiza, Rakesh Kaundal   +2 more
semanticscholar   +1 more source

TRPC1: Subcellular Localization?

Journal of Biological Chemistry, 2010
Berbey et al. (1) recently reported that overexpressed TRPC1-YFP fusion protein is targeted to the sarcoplasmic reticulum of adult skeletal muscle fibers and operates as a calcium leak channel. This observation is in accordance with previous reports showing that the movement of TRPC1 to the plasma membrane is dependent on co-expression with TRPC4 or ...
Nicolas Tajeddine, Nadège Zanou, Monique Van Schoor, Jean Lebacq, Philippe Gailly   +4 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

ComPPI: a cellular compartment-specific database for protein-protein interaction network analysis [PDF]

, 2015
Here we present ComPPI, a cellular compartment-specific database of proteins and their interactions enabling an extensive, compartmentalized protein-protein interaction network analysis (URL: http://ComPPI.LinkGroup.hu). ComPPI enables the user to filter
Csermely, Péter, Fazekas, Dávid, Gyurkó, Márton Dávid, Korcsmáros, Tamás, Szalay, Kristóf Zsolt, Thaler B, Veres, Dániel   +6 more
core  

Green Fluorescent Protein- and Discosoma sp. Red Fluorescent Protein-Tagged Organelle Marker Lines for Protein Subcellular Localization in Rice

Frontiers in Plant Science, 2019
The subcellular localization of proteins is a fundamental aspect of protein functions. Determining the subcellular localization is important for understanding the biological functions of proteins.
Ziqiang Chen, Wenhui Zheng, Wenhui Zheng, Longhai Chen, Chenlu Li, Tingmin Liang, Zaijie Chen, Huibing Xu, Yijuan Han, Lan Kong, Xu Zhao, Feng Wang, Zonghua Wang, Zonghua Wang, Songbiao Chen   +14 more
doaj   +1 more source

Mechanical Fractionation of Cultured Neuronal Cells into Cell Body and Neurite Fractions

Bio-Protocol, 2021
Many cells contain spatially defined subcellular regions that perform specialized tasks enabled by localized proteins. The subcellular distribution of these localized proteins is often facilitated by the subcellular localization of the RNA molecules that
Ankita Arora, Raeann Goering, Hei-Yong Lo, J. Taliaferro   +3 more
doaj   +1 more source