Results 81 to 90 of about 820,988 (298)

Identify RNA-associated subcellular localizations based on multi-label learning using Chou’s 5-steps rule

BMC Genomics, 2021
Background Biological functions of biomolecules rely on the cellular compartments where they are located in cells. Importantly, RNAs are assigned in specific locations of a cell, enabling the cell to implement diverse biochemical processes in the way of ...
Hao Wang, Yijie Ding, Jijun Tang, Quan Zou, Fei Guo   +4 more
doaj   +1 more source

DRpred: A Novel Deep Learning-Based Predictor for Multi-Label mRNA Subcellular Localization Prediction by Incorporating Bayesian Inferred Prior Label Relationships

Biomolecules
The subcellular localization of messenger RNA (mRNA) not only helps us to understand the localization regulation of gene expression but also helps to understand the relationship between RNA localization pattern and human disease mechanism, which has ...
Xiao Wang, Lixiang Yang, Rong Wang
doaj   +1 more source

MSLP: mRNA subcellular localization predictor based on machine learning techniques

BMC Bioinformatics, 2023
Background Subcellular localization of messenger RNA (mRNAs) plays a pivotal role in the regulation of gene expression, cell migration as well as in cellular adaptation.
Saleh Musleh, Mohammad Tariqul Islam, Rizwan Qureshi, Nehad M. Alajez, Tanvir Alam   +4 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Subcellular Localization Prediction of Eukaryotic Protein

, 2009
[[abstract]]Biologically, the function of a protein is highly related to its subcellular localization. Accordingly, it is necessary to develop an automatic yet reliable method for protein subcellular localization prediction, especially when large-scale ...
Chen Shih Hao
core  

Subcellular localization of CsGAIP protein.

, 2014
(A) Alignment of the N-terminal 200–300 amino acid residues of CsGAIP with AtRGA and AtGAI. The black line indicates the highly conserved nuclear localization signal (NLS) domain.
Jingbo An (535578), Bin Liu (5899), Yan Zhang (8098), Sen Yang (88300), Xiaolan Zhang (76101), Chunhua Chen (75707), Huazhong Ren (513737)   +6 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

LncSTPred: a predictive model of lncRNA subcellular localization and decipherment of the biological determinants influencing localization

Frontiers in Molecular Biosciences
IntroductionLong non-coding RNAs (lncRNAs) play crucial roles in genetic markers, genome rearrangement, chromatin modifications, and other biological processes.
Si-Le Hu, Ying-Li Chen, Lu-Qiang Zhang, Hui Bai, Jia-Hong Yang, Qian-Zhong Li, Qian-Zhong Li   +6 more
doaj   +1 more source

LOCATE: A mammalian protein subcellular localization database

, 2008
LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of mouse and human proteins. Over the past 2 years, the data in LOCATE have grown substantially.
Hanson, K., Karunaratne, S., Teasdale, R. D., Fink, L., Sprenger, J., Hamilton, N. A.   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source