Results 61 to 70 of about 855,524 (247)

Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge

BMC Molecular and Cell Biology, 2019
Background Whole-proteome distributions of protein isoelectric point (pI) values in different organisms are bi- or trimodal with some variations. It was suggested that the observed multimodality of the proteome-wide pI distributions is associated with ...
Atsushi Kurotani, Alexander A. Tokmakov, Ken-Ichi Sato, Vasily E. Stefanov, Yutaka Yamada, Tetsuya Sakurai   +5 more
doaj   +1 more source

Mechanical Fractionation of Cultured Neuronal Cells into Cell Body and Neurite Fractions

Bio-Protocol, 2021
Many cells contain spatially defined subcellular regions that perform specialized tasks enabled by localized proteins. The subcellular distribution of these localized proteins is often facilitated by the subcellular localization of the RNA molecules that
Ankita Arora, Raeann Goering, Hei-Yong Lo, J. Taliaferro   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Driving forces for the subcellular localization of peripheral proteins.

, 2003
Driving forces for the subcellular localization of peripheral ...
Robert Virgil. Stahelin (7969454)
core   +4 more sources

Unified mRNA Subcellular Localization Predictor based on machine learning techniques

BMC Genomics
Background The mRNA subcellular localization bears substantial impact in the regulation of gene expression, cellular migration, and adaptation. However, the methods employed for experimental determination of this localization are arduous, time-intensive,
Saleh Musleh, Muhammad Arif, Nehad M. Alajez, Tanvir Alam   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Attentional BiLSTM and Prototype Networks for lncRNA Subcellular Localization Prediction [PDF]

Jisuanji gongcheng
Long non-coding RNA (lncRNA) are crucial in many cellular life processes, and their subcellular localization can provide key information for their functional identification.
SUN Rongneng, LIU Lin, KANG Yuanzhao
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

ELLA: modeling subcellular spatial variation of gene expression within cells in high-resolution spatial transcriptomics

Nature Communications
Spatial transcriptomics technologies are becoming increasingly high-resolution, enabling gene expression measurement at the subcellular level. Here, we present subcellular expression localization analysis (ELLA), a statistical framework for modeling ...
Jade Xiaoqing Wang, Xiang Zhou
doaj   +1 more source

Prediction of Protein Subcellular Localization: A Machine Learning Approach [PDF]

, 2010
Subcellular localization is a key functional characteristic of proteins. Optimally combining available information is one of the key challenges in today's knowledge-based subcellular localization prediction approaches.
SHIM, Kyong Jin
core