Results 61 to 70 of about 820,988 (298)

Subcellular localization prediction of the shortlisted proteins.

, 2023
Subcellular localization prediction of the shortlisted proteins.
Abbas Ahmad (16517912), Asifullah Khan (5901902), Yasir Ali (799969), Musaed Alkholief (4288102), Sara Aiman (9090834), Abdul Malik (319406), Suhail Akhtar (767316), Chunhua Li (18618), Fazal Jalil (9396338), Raham Sher Khan (17442136)   +9 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Green Fluorescent Protein- and Discosoma sp. Red Fluorescent Protein-Tagged Organelle Marker Lines for Protein Subcellular Localization in Rice

Frontiers in Plant Science, 2019
The subcellular localization of proteins is a fundamental aspect of protein functions. Determining the subcellular localization is important for understanding the biological functions of proteins.
Ziqiang Chen, Wenhui Zheng, Wenhui Zheng, Longhai Chen, Chenlu Li, Tingmin Liang, Zaijie Chen, Huibing Xu, Yijuan Han, Lan Kong, Xu Zhao, Feng Wang, Zonghua Wang, Zonghua Wang, Songbiao Chen   +14 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Mechanical Fractionation of Cultured Neuronal Cells into Cell Body and Neurite Fractions

Bio-Protocol, 2021
Many cells contain spatially defined subcellular regions that perform specialized tasks enabled by localized proteins. The subcellular distribution of these localized proteins is often facilitated by the subcellular localization of the RNA molecules that
Ankita Arora, Raeann Goering, Hei-Yong Lo, J. Taliaferro   +3 more
doaj   +1 more source

Subcellular localization of Rab27a.

, 2015
(A) Subcellular localization of Rab27a and lipid droplet in uninfected Huh7 cells. (B) Subcellular localization of Rab27a (red), HCV core (blue) and lipid droplets in HCV-infected cells at day 3 post-infection. Lipid droplets were stained with Bodipy 493/
Chung-Han Hsieh (787256), Peter Sarnow (241645), Tzu-Chun Chen (787255)   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Localization-specific distributions of protein pI in human proteome are governed by local pH and membrane charge

BMC Molecular and Cell Biology, 2019
Background Whole-proteome distributions of protein isoelectric point (pI) values in different organisms are bi- or trimodal with some variations. It was suggested that the observed multimodality of the proteome-wide pI distributions is associated with ...
Atsushi Kurotani, Alexander A. Tokmakov, Ken-Ichi Sato, Vasily E. Stefanov, Yutaka Yamada, Tetsuya Sakurai   +5 more
doaj   +1 more source

Subcellular Localization and Regulation of Coenzyme A Synthase [PDF]

Journal of Biological Chemistry, 2003
CoA synthase mediates the last two steps in the sequence of enzymatic reactions, leading to CoA biosynthesis. We have recently identified cDNA for CoA synthase and demonstrated that it encodes a bifunctional enzyme possessing 4'-phosphopantetheine adenylyltransferase and dephospho-CoA kinase activities.
Zhyvoloup, A, Nemazanyy, I, Panasyuk, G, Valovka, T, Fenton, TR, Rebholz, H, Wang, ML, Foxon, R, Lyzogubov, V, Usenko, V, Kyyamova, R, Gorbenko, O, Matsuka, G, Filonenko, V, Gout, IT   +14 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source