Results 51 to 60 of about 855,524 (247)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Subcellular localization of Rab27a.

, 2015
(A) Subcellular localization of Rab27a and lipid droplet in uninfected Huh7 cells. (B) Subcellular localization of Rab27a (red), HCV core (blue) and lipid droplets in HCV-infected cells at day 3 post-infection. Lipid droplets were stained with Bodipy 493/
Chung-Han Hsieh (787256), Peter Sarnow (241645), Tzu-Chun Chen (787255)   +2 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

LocPro: A deep learning-based prediction of protein subcellular localization for promoting multi-directional pharmaceutical research

Journal of Pharmaceutical Analysis
Drug development encompasses multiple processes, wherein protein subcellular localization is essential. It promotes target identification, treatment development, and the design of drug delivery systems.
Yintao Zhang, Lingyan Zheng, Nanxin You, Wei Hu, Wanghao Jiang, Mingkun Lu, Hangwei Xu, Haibin Dai, Tingting Fu, Ying Zhou   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Green Fluorescent Protein- and Discosoma sp. Red Fluorescent Protein-Tagged Organelle Marker Lines for Protein Subcellular Localization in Rice

Frontiers in Plant Science, 2019
The subcellular localization of proteins is a fundamental aspect of protein functions. Determining the subcellular localization is important for understanding the biological functions of proteins.
Ziqiang Chen, Wenhui Zheng, Wenhui Zheng, Longhai Chen, Chenlu Li, Tingmin Liang, Zaijie Chen, Huibing Xu, Yijuan Han, Lan Kong, Xu Zhao, Feng Wang, Zonghua Wang, Zonghua Wang, Songbiao Chen   +14 more
doaj   +1 more source

Changes in Subcellular Localization of Host Proteins Induced by Plant Viruses

Viruses, 2021
Viruses are dependent on host factors at all parts of the infection cycle, such as translation, genome replication, encapsidation, and cell-to-cell and systemic movement.
Rosalba Rodriguez-Peña, Kaoutar El Mounadi, Hernan Garcia-Ruiz   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Subcellular localization of HbFd1 in Arabidopsis protoplast.

, 2015
(A) The vectors were used for subcellular localization. (B) Subcellular localization of HbFd1::GFP (top panel) with GFP as the positive control (middle panel) and empty vector as the negative control (bottom panel).
Junwen Zhang (833829), Ruifen Li (833831), Jianhua Wei (166924), Hongzhi Wang (617138), Chao Zhang (51048), Yajuan Chen (833830), Rongchao Ge (833828)   +6 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source