A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein. [PDF]
, 2018 Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including ...
Barry, Kerrie +12 more
core +1 more source
Protein localization as a principal feature of the etiology and comorbidity of genetic diseases
Molecular Systems Biology, 2011 Proteins targeting the same subcellular localization tend to participate in mutual protein–protein interactions (PPIs) and are often functionally associated. Here, we investigated the relationship between disease‐associated proteins and their subcellular
Solip Park +5 more
doaj +1 more source
Protein Subcellular Localization in Bacteria [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Like their eukaryotic counterparts, bacterial cells have a highly organized internal architecture. Here, we address the question of how proteins localize to particular sites in the cell and how they do so in a dynamic manner. We consider the underlying mechanisms that govern the positioning of proteins and protein complexes in the examples of the ...
David Z, Rudner, Richard, Losick
openaire +2 more sources
Multi-label multi-kernel transfer learning for human protein subcellular localization. [PDF]
PLoS ONE, 2012 Recent years have witnessed much progress in computational modelling for protein subcellular localization. However, the existing sequence-based predictive models demonstrate moderate or unsatisfactory performance, and the gene ontology (GO) based models ...
Suyu Mei
doaj +1 more source
Convolutional LSTM Networks for Subcellular Localization of Proteins [PDF]
, 2015 Machine learning is widely used to analyze biological sequence data. Non-sequential models such as SVMs or feed-forward neural networks are often used although they have no natural way of handling sequences of varying length.
A Graves +19 more
core +3 more sources
Bioinform., 2010 Motivation: PSORTb has remained the most precise bacterial protein subcellular localization (SCL) predictor since it was first made available in 2003.
N. Y. Yu +10 more
semanticscholar +1 more source
A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins
bioRxiv, 2020 Coronavirus possesses the largest RNA genome among all the RNA viruses. Its genome encodes about 29 proteins. Most of the viral proteins are non-structural proteins (NSP) except envelop (E), membrane (M), nucleocapsid (N) and Spike (S) proteins that ...
Jing Zhang +7 more
semanticscholar +1 more source
DeepmRNALoc: A Novel Predictor of Eukaryotic mRNA Subcellular Localization Based on Deep Learning
Molecules, 2023 The subcellular localization of messenger RNA (mRNA) precisely controls where protein products are synthesized and where they function. However, obtaining an mRNA’s subcellular localization through wet-lab experiments is time-consuming and expensive, and
Shihang Wang +5 more
doaj +1 more source
Microtubule-dependent ribosome localization in C. elegans neurons. [PDF]
, 2017 Subcellular localization of ribosomes defines the location and capacity for protein synthesis. Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic investigations of the cell biology of ribosome dynamics. Here,
Ellisman, Mark H +3 more
core +1 more source
RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]
, 2020 Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe +4 more
core +1 more source