DBMLoc: a Database of proteins with multiple subcellular localizations
BMC Bioinformatics, 2008 Background Subcellular localization information is one of the key features to protein function research. Locating to a specific subcellular compartment is essential for a protein to function efficiently.
Zhou Yun +4 more
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Sequence conserved for subcellular localization [PDF]
Protein Science, 2002 AbstractThe more proteins diverged in sequence, the more difficult it becomes for bioinformatics to infer similarities of protein function and structure from sequence. The precise thresholds used in automated genome annotations depend on the particular aspect of protein function transferred by homology. Here, we presented the first large‐scale analysis
Rajesh, Nair, Burkhard, Rost
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Quantitative protein localization signatures reveal an association between spatial and functional divergences of proteins. [PDF]
PLoS Computational Biology, 2014 Protein subcellular localization is a major determinant of protein function. However, this important protein feature is often described in terms of discrete and qualitative categories of subcellular compartments, and therefore it has limited applications
Lit-Hsin Loo +2 more
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Protein localization as a principal feature of the etiology and comorbidity of genetic diseases
Molecular Systems Biology, 2011 Proteins targeting the same subcellular localization tend to participate in mutual protein–protein interactions (PPIs) and are often functionally associated. Here, we investigated the relationship between disease‐associated proteins and their subcellular
Solip Park +5 more
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DeepmRNALoc: A Novel Predictor of Eukaryotic mRNA Subcellular Localization Based on Deep Learning
Molecules, 2023 The subcellular localization of messenger RNA (mRNA) precisely controls where protein products are synthesized and where they function. However, obtaining an mRNA’s subcellular localization through wet-lab experiments is time-consuming and expensive, and
Shihang Wang +5 more
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Subcellular localization of Trypanosoma cruzi arginine kinase [PDF]
, 2009 Phosphoarginine is a cell energy buffer molecule synthesized by the enzyme arginine kinase. In Trypanosoma cruzi, the aetiological agent of Chagas’ disease, 2 different isoforms were identified by data mining, but only 1 was expressed during the parasite
Pereira, Claudio Alejandro +3 more
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Multi-label multi-kernel transfer learning for human protein subcellular localization. [PDF]
PLoS ONE, 2012 Recent years have witnessed much progress in computational modelling for protein subcellular localization. However, the existing sequence-based predictive models demonstrate moderate or unsatisfactory performance, and the gene ontology (GO) based models ...
Suyu Mei
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Global Positioning System: Understanding Long Noncoding RNAs through Subcellular Localization. [PDF]
, 2019 The localization of long noncoding RNAs (lncRNAs) within the cell is the primary determinant of their molecular functions. LncRNAs are often thought of as chromatin-restricted regulators of gene transcription and chromatin structure.
Carlevaro-Fita, Joana, Johnson, Rory
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LncATLAS database for subcellular localization of long noncoding RNAs [PDF]
, 2017 The subcellular localization of long noncoding RNAs (lncRNAs) holds valuable clues to their molecular function. However, measuring localization of newly discovered lncRNAs involves time-consuming and costly experimental methods.
Carlevaro Fita, Joana +15 more
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Mechanisms of Subcellular mRNA Localization [PDF]
Cell, 2002 Localization of RNA is a widespread and efficient way to target gene products to a specific region of a cell or embryo. This strategy of posttranscriptional gene regulation utilizes a variety of distinct mechanisms to regulate the movement and anchoring of different transcripts.
Kloc, Malgorzata +2 more
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