A review from biological mapping to computation-based subcellular localization
Molecular Therapy: Nucleic Acids, 2023 Subcellular localization is crucial to the study of virus and diseases. Specifically, research on protein subcellular localization can help identify clues between virus and host cells that can aid in the design of targeted drugs.
Jing Li, Quan Zou, Lei Yuan
doaj +2 more sources
CELLO2GO: A Web Server for Protein subCELlular LOcalization Prediction with Functional Gene Ontology Annotation [PDF]
PLoS ONE, 2014 CELLO2GO (http://cello.life.nctu.edu.tw/cello2go/) is a publicly available, web-based system for screening various properties of a targeted protein and its subcellular localization.
Shao-Wei Huang +2 more
exaly +2 more sources
Decoding subcellular RNA localization one molecule at a time
Genome BiologyEukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological processes.
Josep Biayna, Gabrijela Dumbović
doaj +2 more sources
Recent Advances in the Prediction of Subcellular Localization of Proteins and Related Topics
Frontiers in Bioinformatics, 2022 Prediction of subcellular localization of proteins from their amino acid sequences has a long history in bioinformatics and is still actively developing, incorporating the latest advances in machine learning and proteomics.
Kenta Nakai, Leyi Wei
exaly +3 more sources
PSI: A Comprehensive and Integrative Approach for Accurate Plant Subcellular Localization Prediction [PDF]
PLoS ONE, 2013 Predicting the subcellular localization of proteins conquers the major drawbacks of high-throughput localization experiments that are costly and time-consuming. However, current subcellular localization predictors are limited in scope and accuracy.
Ming Chen, Qian Mei
exaly +2 more sources
Protein subcellular localization prediction tools
Computational and Structural Biotechnology JournalProtein subcellular localization prediction is of great significance in bioinformatics and biological research. Most of the proteins do not have experimentally determined localization information, computational prediction methods and tools have been ...
Maryam Gillani, Gianluca Pollastri
exaly +3 more sources
Research progress on subcellular localization and function of long non-coding RNA [PDF]
Jichu yixue yu linchuang, 2023 The subcellular localization of long non-coding RNA(lncRNA) is closely related to its function. When localized in the nucleus, lncRNA can maintain chromatin structure, regulate gene transcription and participate in variable splicing of mRNA.
SU Yue, LIANG Linhui, HE Xianghuo
doaj +1 more source
Prediction of protein subcellular localization using support vector machine with the choice of proper kernel [PDF]
BioTechnologia, 2017 The prediction of subcellular locations of proteins can provide useful hints for revealing their functions as well as for understanding the mechanisms of some diseases and, finally, for developing novel drugs.
Al Mehedi Hasan +2 more
doaj +2 more sources
Threonine 348 regulates the subcellular localization of PTEN. [PDF]
FEBS Open BioThr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Kato T, Tanaka S, Ohashi M.
europepmc +2 more sources
Refining protein subcellular localization. [PDF]
PLoS Computational Biology, 2005 The study of protein subcellular localization is important to elucidate protein function. Even in well-studied organisms such as yeast, experimental methods have not been able to provide a full coverage of localization.
Michelle S Scott +3 more
doaj +2 more sources