Results 141 to 150 of about 5,419,445 (302)
Advanced Science, EarlyView.IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu +8 more
wiley +1 more source
A generic 3D kinetic model of gene expression
Open Physics, 2012 Zhdanov Vladimir
doaj +1 more source
Uptake pathways and subcellular fractionation of Cd in the polychaete Nereis diversicolor
, 2012 Polychaetes have often been utilized as indicator species to investigate the impacts of pollutants, such as heavy metals. The uptake of Cd by the polychaete Nereis diversicolor was determined at varying Ca concentrations and with pre-exposure to Ca ion ...
Wu, Huifeng +5 more
core
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source
Two novel aspects of the kinetics of gene expression including miRNAs
Open Physics, 2013 Zhdanov Vladimir
doaj +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Interplay of viral miRNAs and host mRNAs and proteins
Open Physics, 2011 Zhdanov Vladimir
doaj +1 more source
A flexible ontology for inference of emergent whole cell function from relationships between subcellular processes. [PDF]
Sci Rep, 2017 Hansen J +4 more
europepmc +1 more source
Molecular Sculpting: Active Learning of Subcellular Systems & Processes
The American Biology Teacher, 2016 Students often struggle to understand the complex molecular systems and processes presented in introductory biology courses. These include the Calvin cycle, the Krebs cycle, transcription and translation, and DNA replication, among others. Traditionally, these systems and processes are taught using textbook readings and PowerPoint slides as lecture ...
openaire +1 more source