Results 241 to 250 of about 5,419,445 (302)

Dissecting autonomous enzymatic variability in single cells. [PDF]

Nat Commun
Gnann C, Sigaeva A, Le T, Cesnik AJ, Sariyar S, Mahdessian D, Schutten R, Raghavan P, Leonetti MD, Lindskog C, Uhlén M, Axelsson U, Lundberg E.   +12 more
europepmc   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

How mitochondrial heterogeneity fuels a dynamic organelle ecosystem. [PDF]

Commun Biol
Desmaison PJ, Bertolin G.
europepmc   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Research and application advances in real-time single-cell functional analysis. [PDF]

Discov Nano
Yue Y, Liu X, Yu X.
europepmc   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Subcellular Tandem-Activated Signal Amplification for Spatially Precise Molecular Imaging in Mitochondria. [PDF]

Angew Chem Int Ed Engl
Feng X, Yi D, Li L, Li M.
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling. [PDF]

Adv Sci (Weinh)
Zha F, Feng D, Xue Z, Liu Z, Lin X, Wang Z, Xu L, Chan JFW, Cheung M, Huen MSY, Guo Y, Chan KM, Liu Y, Gao B.   +13 more
europepmc   +1 more source

An integrative bioinformatics framework for functional annotation and prioritization of hypothetical proteins in Bacillus thuringiensis relevant to biological pest control. [PDF]

Braz J Microbiol
Machado V, Kwecko MR, Dos Reis MAP, Galian J.   +3 more
europepmc   +1 more source