Predicting human protein subcellular locations by the ensemble of multiple predictors via protein-protein interaction network with edge clustering coefficients. [PDF]
PLoS ONE, 2014 One of the fundamental tasks in biology is to identify the functions of all proteins to reveal the primary machinery of a cell. Knowledge of the subcellular locations of proteins will provide key hints to reveal their functions and to understand the ...
Pufeng Du, Lusheng Wang
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tRNA Processing and Subcellular Trafficking Proteins Multitask in Pathways for Other RNAs [PDF]
Frontiers in Genetics, 2019 This article focuses upon gene products that are involved in tRNA biology, with particular emphasis upon post-transcriptional RNA processing and nuclear-cytoplasmic subcellular trafficking. Rather than analyzing these proteins solely from a tRNA perspective, we explore the many overlapping functions of the processing enzymes and proteins involved in ...
Anita K. Hopper, Regina T. Nostramo
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Automatic Segmentation of Unstained Living Cells in Bright-Field Microscope Images [PDF]
, 2008 Tscherepanow M, Zöllner F, Hillebrand M, Kummert F. Automatic Segmentation of Unstained Living Cells in Bright-Field Microscope Images. In: Perner P, Salvetti O, eds. Proceedings of the International Conference on Mass-Data Analysis of Images and Signals
Zöllner, Frank +9 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Prediction of protein subcellular localization using support vector machine with the choice of proper kernel [PDF]
, 2017 The prediction of subcellular locations of proteins can provide useful hints for revealing their functions as well as for understanding the mechanisms of some diseases and, finally, for developing novel drugs.
Khademul Islam Molla +5 more
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DNA damage-induced translocation of S100A11 into the nucleus regulates cell proliferation
BMC Cell Biology, 2010 Background Proteins are able to react in response to distinct stress stimuli by alteration of their subcellular distribution. The stress-responsive protein S100A11 belongs to the family of multifunctional S100 proteins which have been implicated in ...
Ulbricht Tobias +5 more
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Subcellular Imaging of Voltage and Calcium Signals Reveals Neural Processing In Vivo [PDF]
Cell, 2016 A mechanistic understanding of neural computation requires determining how information is processed as it passes through neurons and across synapses. However, it has been challenging to measure membrane potential changes in axons and dendrites in vivo.
Helen H, Yang +5 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Nuclear RNA purification by flow cytometry to study nuclear processes in plants
STAR Protocols, 2021 Summary: The nature of plant tissues has continuously hampered understanding of the spatio-temporal and subcellular distribution of RNA-guided processes.
Belén Moro +5 more
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