Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals [PDF]
, 2005 We investigated human alternative protein isoforms of >2600 genes based on full-length cDNA clones and SwissProt. We classified the isoforms and examined their co-occurrence for each gene.
Nakao, M. +5 more
core
Analysis of the Subcellular Phosphoproteome Using a Novel Phosphoproteomic Reactor
, 2010 Protein phosphorylation is an important post-translational modification involved in the regulation of many cellular processes. Mass spectrometry has been successfully used to identify protein phosphorylation in specific pathways and for global ...
Elisma, Fred +10 more
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
, 2015 We have become aware that a review paper [1] recently published in Processes contained a considerable amount of identical text and a similar structure to a previously published review paper [2], although some novel content was presented, including new ...
Michael Henson +3 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Subcellular transcriptomes and proteomes of developing axon projections in cerebral cortex
Subcellular RNA-Proteome Mapping dataset for manuscript Poulopoulos A, Murphy AM,... Macklis JD, 2018 "Subcellular transcriptomes and proteomes of developing axon projections in cerebral ...
Jeffrey D. Macklis +2 more
core +2 more sources
Application of triphenylphosphonium salt in tumor diagnosis and treatment
上海师范大学学报. 自然科学版Subcellular targeted therapy is a new research direction of tumor therapy. It can cause apoptosis by first damaging subcellular organelles or affecting their surrounding environment.
ZHANG Haifeng, AN Lu
doaj +1 more source
Attentional BiLSTM and Prototype Networks for lncRNA Subcellular Localization Prediction [PDF]
Jisuanji gongchengLong non-coding RNA (lncRNA) are crucial in many cellular life processes, and their subcellular localization can provide key information for their functional identification.
SUN Rongneng, LIU Lin, KANG Yuanzhao
doaj +1 more source
Protocol to determine the subcellular localization of protein interactions in murine keratinocytes
STAR Protocols, 2023 Summary: Protein activities and interactions are determined by their subcellular localization. Elucidating the network of protein-protein interactions at a spatial resolution is essential for understanding the complexity of protein functions, their ...
Lisa Müller
doaj +1 more source
Identification of subcellular compartments involved in biosynthetic processing of cathepsin D.
Journal of Biological Chemistry, 1992 We have assigned the biosynthetic processing steps of cathepsin D to intracellular compartments which are involved in its transport to lysosomes in HepG2 cells. Cathepsin D was synthesized as a 51-kDa proenzyme. After formation of 51-55-kDa intermediates due to processing of N-linked oligosaccharides, procathepsin D was proteolytically processed to an ...
Rijnboutt, S +3 more
openaire +3 more sources