Results 61 to 70 of about 191,821 (303)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Subcellular Localization of Glycosidases and Glycosyltransferases Involved in the Processing of N-Linked Oligosaccharides [PDF]

Plant Physiology, 1987
Using isopycnic sucrose gradients, we have ascertained the subcellular location of several enzymes involved in the processing of the N-linked oligosaccharides of glycoproteins in developing cotyledons of the common bean, Phaseolus vulgaris. All are localized in the endoplasmic reticulum (ER) or Golgi complex as determined by co-sedimentation with the ...
A, Sturm, K D, Johnson, T, Szumilo, A D, Elbein, M J, Chrispeels   +4 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Long-term in vivo imaging of Drosophila larvae [PDF]

, 2020
The Drosophila larva has been used to investigate many processes in cell biology, including morphogenesis, physiology and responses to drugs and new therapeutic compounds.
Linda Partridge, Kakanj, P., Leptin, M., Partridge, L, Partridge, L., Parisa Kakanj, Maria Leptin, Eming, SA, Leptin, M, Kakanj, P, Eming, S., Sabine A. Eming   +11 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Super-resolution microscopy and its applications in neuroscience [PDF]

, 2017
Optical microscopy promises researchers to see most tiny substances directly. However, the resolution of conventional microscopy is restricted by the diffraction limit. This makes it a challenge to observe subcellular processes happened in nanoscale. The
Xinpei Zhu, Ke Si, Xuecen Wang, Yao Zheng, Jiahao Wang, Wei Gong   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

House retinal cell behaviour in space and time using light sheet fluorescence microscopy [PDF]

, 2020
As the general population ages, more people are affected by eye diseases, such as retinopathies. It is therefore critical to improve imaging of eye disease mouse models.
Richardson, Douglas, Mead, T., Richards, Mark,, Harrington, Kyle, Mead, Thomas, Mead, Thomas,, Cho, K.S., Ana Figueiredo, Russo, A.M., Harrington, Kyle,, Kin-Sang Cho, Franco, C.A., Venkaraman, Lakshmi, Parham Ashrafzadeh, Chen, J.X., Thomas Mead, Andreia Pena, Kyle Harrington, Richardson, D., Chang, Karen,, Claesson-Welsh, Lena,, Figueiredo, A., Venkaraman, Lakshmi,, Ashrafzadeh, Parham, Ouarne, Marie, Chang, Karen, Cho, Kin-Sang, Pena, Andreia, Claesson-Welsh, L., Russo, Ana Martins,, Claudia Prahst, Bentley, Katie,, Karen Chang, Franco, Claudio A.,, Harrington, K., Claesson-Welsh, Lena, Richards, M., Katie Bentley, Ouarné, M., Ouarne, Marie,, Russo, Ana Martins, Venkaraman, L., Lakshmi Venkaraman, Figueiredo, Ana,, Chen, Dong Feng,, Claudio A Franco, Richards, Mark, Prahst, C., Franco, Claudio A., Bentley, Katie, Prahst, Claudia,, Bentley, K., Pena, A., Dong Feng Chen, Chen, Dong Feng, Marie Ouarné, Cho, Kin-Sang,, Richardson, Douglas,, Prahst, Claudia, Ashrafzadeh, P., Ana Martins Russo, Figueiredo, Ana, Chang, K., Lena Claesson-Welsh, Douglas Richardson, Mark Richards, Pena, Andreia,   +66 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Deciphering subcellular processes in live imaging datasets via dynamic probabilistic networks

, 2010
Motivation: Designing mathematical tools that can formally describe the dynamics of complex intracellular processes remains a challenge. Live cell imaging reveals changes in the cellular states, but current simple approaches extract only minimal ...
Kresimir Letinic, Andrew Barthel, Derek Toomre, Rafael Sebastian   +3 more
core   +1 more source