Results 71 to 80 of about 5,419,445 (302)

LocPro: A deep learning-based prediction of protein subcellular localization for promoting multi-directional pharmaceutical research

Journal of Pharmaceutical Analysis
Drug development encompasses multiple processes, wherein protein subcellular localization is essential. It promotes target identification, treatment development, and the design of drug delivery systems.
Yintao Zhang, Lingyan Zheng, Nanxin You, Wei Hu, Wanghao Jiang, Mingkun Lu, Hangwei Xu, Haibin Dai, Tingting Fu, Ying Zhou   +9 more
doaj   +1 more source

Recent Advances of AIEgens for Targeted Imaging of Subcellular Organelles

, 2021
Fluorescence imaging based on luminogens with aggregation-induced emission(AIE) effect has drawn great attention in recent two decades, due to their superior advantages to overcome the technical difficulties.
Ma, Ke, Kang, Miaomiao, Zhu, Wei, Wang, Dong, Xiao, Peihong, Huang, Jiachang, Song, Nan, Tang, Ben Zhong   +7 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

LncSTPred: a predictive model of lncRNA subcellular localization and decipherment of the biological determinants influencing localization

Frontiers in Molecular Biosciences
IntroductionLong non-coding RNAs (lncRNAs) play crucial roles in genetic markers, genome rearrangement, chromatin modifications, and other biological processes.
Si-Le Hu, Ying-Li Chen, Lu-Qiang Zhang, Hui Bai, Jia-Hong Yang, Qian-Zhong Li, Qian-Zhong Li   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Spatiotemporally Precise Optical Manipulation of Intracellular Molecular Activities

Advanced Science
Controlling chemical processes in live cells is a challenging task. The spatial heterogeneity of biochemical reactions in cells is often overlooked by conventional means of incubating cells with desired chemicals.
Bin Dong, Shivam Mahapatra, Matthew G. Clark, Mark S. Carlsen, Karsten J. Mohn, Seohee Ma, Kent A. Brasseale III, Grace Crim, Chi Zhang   +8 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells

eLife, 2020
Light-inducible dimerization protein modules enable precise temporal and spatial control of biological processes in non-invasive fashion. Among them, Magnets are small modules engineered from the Neurospora crassa photoreceptor Vivid by orthogonalizing ...
Lorena Benedetti, Jonathan S Marvin, Hanieh Falahati, Andres Guillén-Samander, Loren L Looger, Pietro De Camilli   +5 more
doaj   +1 more source