Results 71 to 80 of about 191,821 (303)

LocPro: A deep learning-based prediction of protein subcellular localization for promoting multi-directional pharmaceutical research

Journal of Pharmaceutical Analysis
Drug development encompasses multiple processes, wherein protein subcellular localization is essential. It promotes target identification, treatment development, and the design of drug delivery systems.
Yintao Zhang, Lingyan Zheng, Nanxin You, Wei Hu, Wanghao Jiang, Mingkun Lu, Hangwei Xu, Haibin Dai, Tingting Fu, Ying Zhou   +9 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The myopathy-causing mutation DNM2-S619L leads to defective tubulation in vitro and in developing zebrafish [PDF]

, 2014
DNM2 is a ubiquitously expressed GTPase that regulates multiple subcellular processes. Mutations in DNM2 are a common cause of centronuclear myopathy, a severe disorder characterized by altered skeletal muscle structure and function.
Ann E. Davidson, William R. Telfer, Eva L. Feldman, Elizabeth M. Gibbs, James J. Dowling   +4 more
core   +1 more source

LncSTPred: a predictive model of lncRNA subcellular localization and decipherment of the biological determinants influencing localization

Frontiers in Molecular Biosciences
IntroductionLong non-coding RNAs (lncRNAs) play crucial roles in genetic markers, genome rearrangement, chromatin modifications, and other biological processes.
Si-Le Hu, Ying-Li Chen, Lu-Qiang Zhang, Hui Bai, Jia-Hong Yang, Qian-Zhong Li, Qian-Zhong Li   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Imaging in vivo Neuronal Transport in Genetic Model Organisms Using Microfluidic Devices

, 2011
Microfluidic devices have been developed for imaging behavior and various cellular processes in Caenorhabditis elegans, but not subcellular processes requiring high spatial resolution.
Ahlawat, Shikha, Rau, Kaustubh, Mondal, Sudip, Venkataraman, V, Koushika, Sandhya P   +4 more
core   +1 more source

Spatiotemporally Precise Optical Manipulation of Intracellular Molecular Activities

Advanced Science
Controlling chemical processes in live cells is a challenging task. The spatial heterogeneity of biochemical reactions in cells is often overlooked by conventional means of incubating cells with desired chemicals.
Bin Dong, Shivam Mahapatra, Matthew G. Clark, Mark S. Carlsen, Karsten J. Mohn, Seohee Ma, Kent A. Brasseale III, Grace Crim, Chi Zhang   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Conformational Selection in the Recognition of Phosphorylated Substrates by the Catalytic Domain of Human Pin1

, 2016
Post-translational phosphorylation and the related conformational changes in signaling proteins are responsible for regulating a wide range of subcellular processes.
Donald Hamelberg (665030), Hector A. Velazquez (2149870)   +1 more
core   +1 more source

Spage2vec : Unsupervised representation of localized spatial gene expression signatures

, 2021
Investigations of spatial cellular composition of tissue architectures revealed by multiplexed in situ RNA detection often rely on inaccurate cell segmentation or prior biological knowledge from complementary single cell sequencing experiments.
Wählby, Carolina, Partel, Gabriele, Partel, Gabriele,, Wählby, Carolina,, Gabriele Partel, Carolina Wählby   +5 more
core   +1 more source