Results 91 to 100 of about 191,821 (303)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Central Nervous System axonal regeneration by spatially targeted drug combinations

, 2017
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that ...
Vera Rabinovich, Carlos A. Toro, Ravi Iyengar, Sarah M. Gregorich, Ehud Kaplan, Christopher L. Passaglia, Nicholas P. Johnson, Rosa E. Tolentino, Christopher P. Cardozo, Yuguang Xiong, Mustafa M. Siddiq, Jens Hansen, Robert D. Blitzer, Arjun Singh Yadaw, Yana Zorina, Marie T. Filbin, Sari S. Hannila   +16 more
core   +1 more source

Design and Selection of Heterodimerizing Helical Hairpins for Synthetic Biology

, 2023
Synthetic biology applications would benefit from protein modules of reduced complexity that function orthogonally to cellular components. As many subcellular processes depend on peptide-protein or protein-protein interactions, de novo designed ...
FitzPatrick, Laura, Woolfson, Dek N, Tigue, Natalie, Mylemans, Bram, Andrews, David, Savery, Nigel J, Smith, Abigail J, Herman, Andrew, Baker, Emily G, Rice, Helen M, Edgell, Caitlin L, Naudin, Elise A   +11 more
core   +1 more source

PMLocMSCAM: Predicting miRNA Subcellular Localisations by miRNA Similarities and Cross‐Attention Mechanism

IET Systems Biology
Many studies have shown that microRNAs (miRNAs) play key roles in some important processes and human complicated diseases. In addition, they also have specific physiological roles at different cellular sites.
Jipu Jiang, Cheng Yan
doaj   +1 more source

RNA-binding protein interacting with circular RNAs: potential multitarget therapeutic strategies in ischaemic stroke

Stroke and Vascular Neurology
Numerous single neuroprotective agents have shown promising results in animal studies, but most have fallen short of expectations in large-scale clinical trials and reliable multitarget neuroprotective agents are still lacking in ischaemic stroke ...
Anding Xu, Dan Lu, Yanfang Liu
doaj   +1 more source

First person – Michael Robichaux

Disease Models & Mechanisms, 2022
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers.
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells

Cell Regeneration, 2013
Background: Sorting nexins are a large family of proteins that are associated with various components of the endosome system and they play many roles in processes such as endocytosis, intracellular protein trafficking and cell signaling.
Leilei Zhang, Dajiang Qin, Chunfang Hao, Xiaodong Shu, Duanqing Pei   +4 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source