Results 21 to 30 of about 558,914 (188)

Acute and Sub-chronic Toxicity Studies of Combination of Physalis angulata L. (Cecendet) Extract and Methylprednisolone on Animals

International Journal of Integrated Health Sciences, 2019
Objective: To evaluate the safety of combination of Physalis angulata L. (Cecendet) extract and methylprednisolone through a single dose in mice (acute toxicity) and repeated doses within 90 days in rats (subchronic toxicity).
Elin Yulinah Sukandar, Shiane Hanako Sheba   +1 more
doaj   +1 more source

Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI [PDF]

, 2013
Background An effective NMDA antagonist imaging model may find key utility in advancing schizophrenia drug discovery research. We investigated effects of subchronic treatment with the NMDA antagonist memantine by using behavioural observation and ...
Ver Donck, L., Van der Linden, A, Giugliano, M., Sijbers, J., Sijbers, J, Wuyts, K, Sekar, S, Couto, J, Ver Donck, L, Willems, R, Mackie, C., Steckler, T, Couto, J., Van Der Linden, A., Willems, R., Jonckers, Elisabeth, Jonckers, E., Veraart, J, Van Auderkerke, J, Steckler, T., Giugliano, M, Veraart, J., Wuyts, K., Mackie, C, Van Audekerke, J., Dedeurwaerdere, S., Verhoye, M, Verhoye, M., De Deurwaerdere, S, Sekar, S.   +29 more
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In vivo toxicity evaluation of a standardized extract of Syzygium aqueum leaf

Toxicology Reports, 2014
In this study, the acute and subchronic toxicity effect of the Syzygium aqueum leaf extract (SA) was evaluated. For the acute toxicity study, a single dose of 2000 mg/kg of the SA was given by oral-gavage to male Sprague-Dawley (SD) rats.
Thamilvaani Manaharan, Srikumar Chakravarthi, Ammu Kutty Radhakrishnan, Uma Devi Palanisamy   +3 more
doaj   +1 more source

Study the subchronic toxicity of the drug Dantinorm Baby [PDF]

, 2021
Presents results of a study of subchronic toxicity of homeopathic drug Dantinorm Baby in finished dosage form. The drug in the form of a ready solution was administered daily orally for one month to outbred rats Infanta and chinchilla rabbits at a dose ...
I. V. Alekseev, I. A. Miroshkina, A. S. Lapizkaya, S. V. Alekseeva, K. S. Kachalov, A. D. Zaharov, A. V. Sorokina   +6 more
core   +1 more source

Effects of JointAlive^® on urinalysis of rats in 13-week subchronic toxicity.

, 2023
Effects of JointAlive® on urinalysis of rats in 13-week subchronic toxicity.
Xin Li (51274), Shengcan Zou (17181432), Yuanyuan Wang (20181), Zimin Liu (10509550), Dehai Gao (17181435), Yanling Mu (4737747), Shanglong Wang (12045182), Jiancheng Zong (12045185), Li Li (14993)   +8 more
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Acute and Subchronic Toxicity of Chantaleela Recipe in Rats [PDF]

, 2012
Acute and subchronic toxicities of Chantaleela recipe were studied in both male and female rats. Oral administration of the extract at a single dose of 5,000 mg/kg body weight (5 females, 5 males) did not produce signs of toxicity, behavioral changes ...
Srithiwong, S, Srithiwong, Supachai, Lertprasertsuke, N, Lertprasertsuke,, Nirush, Jaijoy, K, Jaijoy, Kanjana, Soonthornchareonnon, N, Chiruntanat, Nattakarn, Soonthornchareonnon, Noppamas, Chiruntanat, N, Sireeratawong, Seewaboon, Sireeratawong, S, Nanna, U, Nanna, Urarat   +13 more
core   +1 more source

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

Nanomaterials, 2021
Engineered nanomaterials (ENMs) are of significant relevance due to their unique properties, which have been exploited for widespread applications. Cerium oxide nanoparticles (CeO2-NPs) are one of most exploited ENM in the industry due to their excellent
Adrián García-Salvador, Alberto Katsumiti, Elena Rojas, Carol Aristimuño, Mónica Betanzos, Marta Martínez-Moro, Sergio E. Moya, Felipe Goñi-de-Cerio   +7 more
doaj   +1 more source

Acute and subchronic toxicity as well as evaluation of safety pharmacology of modified pulsatilla granules

Journal of Integrative Agriculture, 2017
The present study investigated acute and subchronic toxicity and safety pharmacology of modified pulsatilla granules (MPG) to provide a basis for a comprehensive understanding of MPG toxicity.
Rui-lin JIA, Xu SONG, Yu-fei GUO, Zhong-qiong YIN, Fei LIU, Juan XIONG, Qiu-yan LIU, Ren-yong JIA, Li-xia LI, Yuan-feng ZOU, Li-zi YIN, Chang-liang HE, Xiao-xia LIANG, Gui-zhou YUE   +13 more
doaj   +1 more source

Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]

, 2006
Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Cadot, R., Bourges-Abella, Nathalie, Gallissot, Frédéric, Sabaté, Jean-Philippe, Morel, G., Lambert, A.M., Saillenfait, Anne-Marie   +6 more
core   +1 more source

Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Stem Cell Research & Therapy, 2022
Introduction Mesenchymal stromal cells (MSCs) have opened a new window to treat inflammatory and non-inflammatory diseases. Nonetheless, their clinical applications require rigorous control and monitoring procedures to ensure full compliance with the ...
Behnoosh Tayebi, Mahnaz Babaahmadi, Mohammad Pakzad, Mostafa Hajinasrollah, Farhad Mostafaei, Shahrbanoo Jahangiri, Amir Kamali, Hossein Baharvand, Mohamadreza Baghaban Eslaminejad, Seyedeh-Nafiseh Hassani, Ensiyeh Hajizadeh-Saffar   +10 more
doaj   +1 more source