Modeling pediatric medulloblastoma
Brain Pathology, Volume 30, Issue 3, Page 703-712, May 2020., 2020 Abstract Mouse models of medulloblastoma have proven to be instrumental in understanding disease mechanisms, particularly the role of epigenetic and molecular drivers, and establishing appropriate preclinical pipelines. To date, our research community has developed murine models for all four groups of medulloblastoma, each of which will be critical for
Martine F. Roussel, Jennifer L. Stripay
wiley +1 more source
Baicalin is an inhibitor of subgroup J avian leukosis virus infection
Virus Research, 2018 Avian leukosis virus subgroup J (ALV-J) can cause great economic losses to the poultry industry worldwide. Baicalin, one of the flavonoids present in S.baicalensis Georgi, has been shown to have antiviral activities. To investigate whether baicalin has antiviral effects on the infection of ALV-J in DF-1 cells, the cells were treated with baicalin at ...
Kun, Qian +7 more
openaire +2 more sources
Role of Virus-Encoded microRNAs in Avian Viral Diseases [PDF]
, 2019 To survive in the host cells, viruses have to adapt various strategies, which include the modulation of microRNA (miRNA) pathway through virus-encoded miRNAs to modulate the host cellular environment.
Nair, Venugopal, Yao, Yongxiu
core +2 more sources
Isolation and analysis of a very virulent Marek’s disease virus strain in China [PDF]
, 2013 BACKGROUND: A severe MD was broken out at a farm in Shandong, China, despite FC126 vaccination of the chickens at 1-day-old. The mortality of the flocks reached up to 38.3%.
Hongchao Ma +6 more
core +1 more source
The hr1 and Fusion Peptide Regions of the Subgroup B Avian Sarcoma and Leukosis Virus Envelope Glycoprotein Influence Low pH-Dependent Membrane Fusion [PDF]
, 2007 The avian sarcoma and leukosis virus (ASLV) envelope glycoprotein (Env) is activated to trigger fusion by a two-step mechanism involving receptor-priming and low pH fusion activation.
AJ Dorner +42 more
core +6 more sources
Acquiring Resistance Against a Retroviral Infection via CRISPR/Cas9 Targeted Genome Editing in a Commercial Chicken Line [PDF]
, 2020 Genome editing technology provides new possibilities for animal breeding and aid in understanding host-pathogen interactions. In poultry, retroviruses display one of the most difficult pathogens to control by conventional strategies such as vaccinations.
Bartsch, Denise +11 more
core +1 more source
MicroRNA-23b Promotes Avian Leukosis Virus Subgroup J (ALV-J) Replication by Targeting IRF1 [PDF]
Scientific Reports, 2015 AbstractAvian leukosis virus subgroup J (ALV-J) can cause several different leukemia-like proliferative diseases in the hemopoietic system of chickens. Here, we investigated the transcriptome profiles and miRNA expression profiles of ALV-J-infected and uninfected chicken spleens to identify the genes and miRNAs related to ALV-J invasion.
Zhenhui Li +7 more
openaire +2 more sources
Frontiers in Veterinary Science, 2022 A strain of avian leukosis virus (ALV) belonging to a new envelope subgroup J (ALV-J) emerged in 1988 as a new subgroup of ALV and spread rapidly throughout the world.
Lan Wu +8 more
doaj +1 more source
Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. [PDF]
, 2011 Progenitor cells are considered an important cell of origin of human malignancies. However, there has not been any single gene that can define mammary bipotential progenitor cells, and as such it has not been possible to use genetic methods to introduce ...
Bu, W +10 more
core +2 more sources
Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]
, 2011 Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet +10 more
core +1 more source