Results 31 to 40 of about 98,117 (335)

Scalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability function approach and in vivo pharmacokinetic study

open access: yesDrug Delivery, 2021
Flibanserin (FLB) was approved by FDA for the treatment of pre-menopausal female hypoactive sexual desire disorder (HSDD). FLB suffers from low oral bioavailability (33%) which might be due to hepatic first-pass metabolism in addition to its poor aqueous
Marianne J. Naguib, Amal I. A. Makhlouf
doaj   +1 more source

A survey of drug liking and cravings in patients using sublingual or intranasal ketamine for treatment resistant depression: A preliminary evaluation of real world addictive potential

open access: yesFrontiers in Psychiatry, 2022
Ketamine has gained rapid popularity as a treatment option for treatment resistant depression (TRD). Though seen only in limited contexts, ketamine is a potential drug of abuse, addiction and diversion.
Brittany Chubbs   +6 more
doaj   +1 more source

Compliance with allergen immunotherapy and factors affecting compliance among patients with respiratory allergies

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Background: Allergen-specific immunotherapy (AIT) is safe and effective for the treatment of allergic rhinitis and allergic asthma. However, patient non-compliance is a major barrier to achieving optimal outcomes Objective: To determine the level of ...
Fardous Musa   +3 more
doaj   +1 more source

Single high-dose buprenorphine for opioid craving during withdrawal. [PDF]

open access: yes, 2018
BackgroundOpioid use disorder is one of the most prevalent addiction problems worldwide. Buprenorphine is used as a medication to treat this disorder, but in countries where buprenorphine is unavailable in combination with naloxone, diversion can be a ...
Ahmadi, Jamshid   +3 more
core   +2 more sources

Results from the 5‐year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy

open access: yesJournal of Allergy and Clinical Immunology, 2017
Background: Allergy immunotherapy targets the immunological cause of allergic rhinoconjunctivitis and allergic asthma and has the potential to alter the natural course of allergic disease. Objective: The primary objective was to investigate the effect of
E. Valovirta   +6 more
semanticscholar   +1 more source

Sublingual [PDF]

open access: yesDefinitions, 2020
Um estudo no controle da dor em doentes com câncer, através da Buprenorfina sublingual (Temgesic), foi realizado em 32 pacientes. Foram discutidos os problemas na avaliação c na exata mensuração da dor, tendo sido usadas três escalas para julgar a sua ...
Buprenorfina Sublingual
openaire   +2 more sources

ALLERGEN IMMUNOTHERAPY: EFFICACY, PERSISTENCE, CONSISTENCY, AND COST EFFECTIVENESS

open access: yesRUDN Journal of Medicine, 2018
Although allergen immunotherapy (AIT) has been used for the treatment of allergic rhinitis (AR), allergic conjunctivitis, asthma, stinging insect hypersensitivity, and atopic dermatitis for over 100 years, it has been slow to gain universal acceptance ...
Dana Wallace
doaj   +1 more source

Assessment of sublingual microcirculation in critically ill patients: consensus and debate

open access: yesAnnals of Translational Medicine, 2020
The main concern in shock and resuscitation is whether the microcirculation can carry adequate oxygen to the tissues and remove waste. Identification of an intact coherence between macro- and microcirculation during states of shock and resuscitation ...
Olcay Dilken, B. Ergin, C. Ince
semanticscholar   +1 more source

Fast Dissolving Sublingual Strips: A Novel Approach for the Delivery of Isosorbide Dinitrate [PDF]

open access: yesPharmaceutical Sciences, 2019
Background: Isosorbide dinitrate (ISDN) is used for treating the angina attacks. In addition, oral ISDN is available in immediate and sustained release formulations and the bioavailability of ISDN is about 20-25% when taken orally.
Marzieh Fathei   +6 more
doaj   +1 more source

Preclinical Safety and Pharmacokinetics of Heat Stable Oxytocin in Sublingual Fast-Dissolving Tablet Formulation

open access: yesPharmaceutics, 2022
The work reported here focuses on an evaluation of a novel heat stable formulation of a uterotonic peptide drug oxytocin involving stability testing under elevated temperatures and toxicokinetic response generated by sublingual (SL) administration in ...
Changcheng Zhu, Manjari Lal
doaj   +1 more source

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