Results 91 to 100 of about 1,812,940 (257)

Cancer pain: current practice and emerging targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye   +5 more
wiley   +1 more source

Premedication with midazolam is equally effective via the sublingual and intravenous route of administration [PDF]

open access: yes, 2014
Background. The aim of this study was to investigate the clinical efficacy and potential side effects of sublingual midazolam, used for premedication, in comparison with intravenous midazolam.
IVIĆ, DUBRAVKA   +5 more
core   +1 more source

Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge.

open access: yesPLoS ONE, 2014
Sublingual route offers a safer and more practical approach for delivering vaccines relative to other systemic and mucosal immunization strategies. Here we present evidence demonstrating protection against ovalbumin expressing B16 (B16-OVA) metastatic ...
Shailbala Singh   +4 more
doaj   +1 more source

Adverse reactions and tolerability of high-dose sublingual allergen immunotherapy

open access: yes, 2016
Angel Moral,1 Victoria Moreno,2 Francisco Girón,3 David El-Qutob,4 José D Moure,5 Manuel Alcántara,6 Antonia Padial,7 Alberto G Oehling,8 Carmen Millán,9 Fernando de la Torre10 1Allergy Service, Hospital Virgen del Valle ...
Moral A   +9 more
core  

Subcutaneous Allergen Immunotherapy With Thermosensitive Hydrogel and Recombinant Birch Pollen Allergen Variant, a Randomised Controlled Trial

open access: yesClinical &Experimental Allergy, EarlyView.
A Phase 1, randomised, placebo‐controlled, dose‐escalation trial was performed with 30 birch pollen allergic subjects treated with DM‐101PX, that contains a recombinant hypoallergenic variant of Bet v 1 formulated with poloxamer 338 thermosensitive hydrogel.
Anna Nilson   +14 more
wiley   +1 more source

Rectal vs. sublingual misoprostol in cesarean section: three‑arm, randomized clinical trial

open access: yesCaspian Journal of Internal Medicine, 2022
Background: Misoprostol is a myometrial stimulant with uterotonic properties and can be administered rectally, vaginally, or sublingually. Numerous studies have investigated the effect of misoprostol on the prevention and treatment of PPH (postpartum ...
Fatemeh Zahra Bagheri   +4 more
doaj  

A comparison of sublingual and intranasal routes for administration of vitamin B12 to human subjects

open access: yes, 2009
Clinical studies have compared the efficacy of intravenous versus intramuscular, orally ingested versus intramuscular, sublingual transmucosal versus intramuscular as well as intranasal transmucosal versus intramuscular vitamin B12 supplementation ...
Ramirez, Maurice Anthony
core  

Serum Estradiol Concentrations With Estradiol 0.06% Gel in Transgender and Gender‐Diverse Adults

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Transgender and gender‐diverse individuals undergoing estradiol therapy for gender affirmation are typically treated with oral or transdermal estradiol, with transdermal estradiol recommended for those aged > 45 years. There are limited data evaluating estradiol gel in gender‐affirming hormone therapy regimens. We aimed to assess the
Raquel A. Maggacis   +2 more
wiley   +1 more source

Visual, vestibular, and ocular motor changes during nitroglycerin‐triggered vestibular migraine

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary Vestibular migraine (VM) is a common cause of intermittent dizziness, but there have been no studies with provoked (induced) VM used to characterize how the vestibular and ocular (vision) systems interact. We injected 20 patients with VM with nitroglycerin to provoke an attack and used a specialized camera to record their eye ...
Maria Dolores Villar‐Martinez   +4 more
wiley   +1 more source

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