Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Que signifient nos perceptions ? Locke, l'anamorphose et le miroir
Methodos, 2016 Locke’s theory of perception has been considered sometimes as a kind of representationalism (Thomas Reid, Michael Ayers), and sometimes as a special case of direct realism (John Yolton, Peter Alexander).
Lucien Vinciguerra
doaj +1 more source
Whatever happened to meaning? Commentary on Millikan: A common structure for concepts of individuals, stuffs, and real kinds [PDF]
, 1998 Even in infancy, concept formation has to do with creating meaning, not with tracking substances. Preverbal infants can identify a substance such as a dog, but their first concept of this substance is not dog but animal.
Mandler, JM
core
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung. [PDF]
, 1987 Norma P. Stimler-Gerard
openalex +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Non-Standard Stainless: Laruelle, Inconsistency and Sense-impressions
Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2018 "Stains" can serve as a metaphor for the role allotted to meaninglessness not only by partisans of the deterritorializing force of "brute matter", but also by diagnosers of symbolic incompleteness.
David Bremner
doaj
Substance abuse treatment: what do we know? an economist's perspective [PDF]
, 2003 The substance abuse treatment literature has basically dealt with four important questions: 1) Is treatment effective? 2) Are all programs equally effective? 3) why do programs differ in their effectiveness?
Machado, Matilde P.
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Historical Implications of Indigenous People and Substance Abuse in the United States
, 2023 Sophia Isabel Barandiaran
openalex +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source