Results 121 to 130 of about 262,152 (305)

Coincident Fluorescence‐Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles From Human Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen, Aleksandr Barulin, Won Jong Yu, Jong‐Chan Park, Inki Kim   +4 more
wiley   +1 more source

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Atomic‐Scale Tailoring of Ni‐Rich Cathodes for the Development of Commercial Li‐Ion Batteries: From Laboratory to Market

Advanced Science, EarlyView.
The growing demand in the lithium‐ion battery industry requires the efficient development of commercial batteries that approach theoretical limits within well‐established systems. In this work, we develop a strategy for controlling the voltage profile under fixed cut‐off voltages in commercial cells by utilizing Ni‐rich cathodes. We establish an atomic‐
Joonhyeon Kang, Sanghyun Lee, Young Cheol Choi, Seungjun Myeong, Sinyoung Park, Hyo Seok Kang, Jia Shin, June Woo Lee, Minkyu You, Sun Sik Shin, Yung Jong Lee, Mira Im, Jong Keun Lee, Jongpil Jegal, Kwan Soo Lee, Cheol‐Hee Park   +15 more
wiley   +1 more source

Effects of Behavioral Activation/Inhibition Systems as Predictors of Substance Abuse in Bipolar Patients

, 2018
Valiollah Akbari, Parvin Rahmatinejad, Seyed Davood Mohammadi, Amene Rudhelle   +3 more
openalex   +2 more sources

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

A pH‐Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury

Advanced Science, EarlyView.
A biomimetic nanoplatform (CeAst@MK) is engineered for precise therapy of acute kidney injury by integrating cerium‐based antioxidation, natural flavonoid astragalin, and macrophage membrane camouflage. Featuring kidney‐targeted and pH‐responsive release, CeAst@MK scavenges ROS, suppresses inflammation, and restores renal function via modulation of ...
Shichao Zhang, Yuhan Xie, Longchao Zhang, Yuanjiong Qi, Quan Liao, Chenglong Xu, Shushuai Yang, Haiwen Zhou, Qidan Tan, Shiyong Qi   +9 more
wiley   +1 more source

The relationship of university students' attitudes towards future with substance abuse proclivity. [PDF]

BMC Public Health
Özer D, Şahin Altun Ö, Akyüz M.
europepmc   +1 more source

Referee report. For: Prevalence of substance abuse and its associated factors among medical students: a cross-sectional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved]

, 2023
Sudhir Raman Parajuli
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

The unique associations of sexual assault and intimate partner violence with PTSD symptom clusters in a traumatized substance-abusing sample.

, 2016
Emily R. Dworkin, Natalie Mota, Julie A. Schumacher, Christine Vinci, Scott F. Coffey   +4 more
openalex   +1 more source