Results 1 to 10 of about 22,206,938 (427)
Substance P: An Inflammatory Peptide [PDF]
European Journal of Inflammation, 2008 Substance P (SP) is involved in neurogenic inflammation and in the pathogenesis of several inflammatory diseases, demonstrating that there is a narrow interrelationship between the nervous system and immunity. Macrophage functions are altered in stress, therefore, since SP is a macrophage activator, its biological effect has been intimately linked to ...
Katsanos, G. S. +6 more
openaire +4 more sources
Proteolysis Controls Endogenous Substance P Levels [PDF]
PLoS ONE, 2013 Substance P (SP) is a prototypical neuropeptide with roles in pain and inflammation. Numerous mechanisms regulate endogenous SP levels, including the differential expression of SP mRNA and the controlled secretion of SP from neurons. Proteolysis has long
Lone, Anna Mari +3 more
core +7 more sources
Substance P-Friend or Foe. [PDF]
J Clin Med, 2022 Substance P (SP), a neuropeptide and pain transmitter has multiple roles and is involved in various processes in the body [...]
Robinson P, Rodriguez E, Muñoz M.
europepmc +4 more sources
Journal of Investigative Dermatology, 1981 Bernstein, Joel E., Hamill, J. Robert
core +3 more sources
J Indian Soc PeriodontolSubstance P (SP), a neuropeptide primarily released by neurons, has emerged as a key player in the intricate network of factors governing periodontal inflammation, immune responses, bone metabolism, and tissue regeneration.
Jayanthi A, Tiwari D, Puzhankara L.
europepmc +2 more sources
A paradox from a neurotransmitter: the opposite effects of substance P and its physiological fragments SP (1-7) and SP (9-11) on the proliferation of human breast cancer cells and the migration capabilities of HUVEC cells [PDF]
World Cancer Research Journal, 2022 OBJECTIVE: Substance P (SP) is a neurotransmitter peptide, and it is known to play a major role in neurogenic inflammation, inducing local inflammatory responses, cancer, and angiogenesis.
O. Koçak, E. Şimşek
doaj +1 more source
Mediterranean Journal of Clinical Psychology, 2023 It is common for a general practitioner to meet patients who suffer from mental disorders such as depression or anxiety in the context of Primary Care (Alexander et al., 2008; Anthony et al., 2010; Consensus ISS, 2022; Regier et al. 1978, 1993; Goldberg
Bianca Vivit +8 more
doaj +1 more source
AIMS Molecular Science, 2021 Gracile axonal dystrophy (gad) mouse shows tremor, ataxia and muscular atrophy of hind limbs from about 80-days of age. These clinical features become progressively severe to death. Pathological examination reveals that main and early axonal degeneration
Tateki Kikuchi
doaj +1 more source
Proliferative effects of metamizole sodium on U-87 MG glioblastoma cell line: a pain killer or a killer? [PDF]
World Cancer Research Journal, 2021 OBJECTIVE: During cancer treatment, painkillers are often used to alleviate patient pain. Metamizole is a pyrazolone derivative and a non-opioid pain reliever.
O. Koçak, E. Şimşek
doaj +1 more source
Open Chemistry, 2020 Clopidogrel (CLOP) is widely used worldwide for cardiovascular complications. CLOP is highly metabolized in the liver to its active metabolite by cytochrome P450 enzymes.
Alhazmi Hassan A. +5 more
doaj +1 more source