Results 1 to 10 of about 2,039,151 (340)

Proteolysis controls endogenous substance P levels. [PDF]

open access: yesPLoS ONE, 2013
Substance P (SP) is a prototypical neuropeptide with roles in pain and inflammation. Numerous mechanisms regulate endogenous SP levels, including the differential expression of SP mRNA and the controlled secretion of SP from neurons. Proteolysis has long
Andrew J Mitchell   +3 more
doaj   +6 more sources

Substance P-A neuropeptide regulator of periodontal disease pathogenesis and potential novel therapeutic entity: A narrative review

open access: yesJournal of Indian Society of Periodontology
Substance P (SP), a neuropeptide primarily released by neurons, has emerged as a key player in the intricate network of factors governing periodontal inflammation, immune responses, bone metabolism, and tissue regeneration.
A Jayanthi, D Tiwari, L Puzhankara
doaj   +2 more sources

A paradox from a neurotransmitter: the opposite effects of substance P and its physiological fragments SP (1-7) and SP (9-11) on the proliferation of human breast cancer cells and the migration capabilities of HUVEC cells [PDF]

open access: yesWorld Cancer Research Journal, 2022
OBJECTIVE: Substance P (SP) is a neurotransmitter peptide, and it is known to play a major role in neurogenic inflammation, inducing local inflammatory responses, cancer, and angiogenesis.
O. Koçak, E. Şimşek
doaj   +1 more source

The impact of psychological assistance in Italian Primary Care: data collected from 2016 to 2018 in the district of Bologna

open access: yesMediterranean Journal of Clinical Psychology, 2023
It is common for a general practitioner to meet patients who suffer from mental disorders such as depression or anxiety in the context of Primary Care (Alexander et al., 2008; Anthony et al., 2010; Consensus ISS, 2022; Regier et al. 1978, 1993; Goldberg
Bianca Vivit   +8 more
doaj   +1 more source

Chronic Kidney Disease Has No Impact on Tear Film Substance P Concentration in Type 2 Diabetes

open access: yesBiomedicines, 2023
Purpose: The study aimed to ascertain the potential effects of chronic kidney disease (CKD) on substance P concentration in the tear film of people with type 2 diabetes.
Kofi Asiedu   +6 more
doaj   +1 more source

Exploring the effect of khat (Catha edulis) chewing on the pharmacokinetics of the antiplatelet drug clopidogrel in rats using the newly developed LC-MS/MS technique

open access: yesOpen Chemistry, 2020
Clopidogrel (CLOP) is widely used worldwide for cardiovascular complications. CLOP is highly metabolized in the liver to its active metabolite by cytochrome P450 enzymes.
Alhazmi Hassan A.   +5 more
doaj   +1 more source

Susbstance P Levels in Children with Atopic Dermatitis

open access: yesBerkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2021
Background: Atopic dermatitis (AD) is the most common skin disease in infants and children. AD is influenced by hereditary and environmental factors, and it is characterized by an inflammatory reaction in the skin.
Khairina Nasution   +2 more
doaj   +1 more source

Spinal relay neurons for central control of autonomic pathways in a photoperiodic rodent [PDF]

open access: yesJournal of Integrative Neuroscience, 2021
Location and distribution of spinal sympathetic preganglionic neurons projecting to the superior cervical ganglion were investigated in a rodent model organism for photoperiodic regulation, the Djungarian hamster (Phodopus sungorus).
Stefan Reuss
doaj   +1 more source

Postoperative healing after surgical removal of mandibular third molar: A comparative study between two proteolytic enzymes

open access: yesJournal of Pharmacy and Bioallied Sciences, 2020
Objective: The postoperative symptoms after third molar removal surgery were commonly uneventful. The aim of this study was to compare two proteolytic enzymes from different origin and to prove which enzyme provides a faster healing.
S Tharani Kumar   +5 more
doaj   +1 more source

Correlation of pain with substance P and neurokinin-1 receptor in the L5–S2 spinal cord in rats with chronic nonbacterial prostatitis [PDF]

open access: yesJournal of Men's Health, 2023
The incidence of prostate pain is 90%–95% in prostatitis. The symptoms are persistent, which is prone to relapse and difficult to be cured. It seriously affects the survival and quality of life of patients.
Liya Hao   +5 more
doaj   +1 more source

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