Results 91 to 100 of about 2,039,151 (340)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Effects of parent-child affective quality during high school years on subsequent substance use [PDF]
, 2012 The literature indicates that the quality of affective relationships between youth and parents is associated with lower levels of a range of problem behaviors during childhood, early and late adolescence.
Ralston, Ekaterina S. +2 more
core +2 more sources
Experimental and clinical studies on an anti-tumor activity of OX substance [PDF]
, 1964 1) OX substance showed marked cytotoxicities in cell suspension culture of Yoshida sarcoma cells, celothelioma cells, and Ehrlich ascites tumor cells. It has become clear that the cytotoxicities have two aspects; one, nuclear shrinkage and karyolisis as ...
Ofuji, Tadashi
core +1 more source
Substance P and pain chronicity [PDF]
Cell and Tissue Research, 2018 Substance P (SP) is a highly conserved member of the tachykinin peptide family that is widely expressed throughout the animal kingdom. The numerous members of the tachykinin peptide family are involved in a multitude of neuronal signaling pathways, mediating sensations and emotional responses (Steinhoff et al. in Physiol Rev 94:265-301, 2014).
openaire +3 more sources
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Journal of Education, Health and Sport, 2019 In an experimental prospective controlled study the leukocyte response of peripheral blood on the background of blockade of receptors of substance P was studied on the carrageenan model of secondary chronic inflammation in 132 rats.
O. M. Shevchenko, V. O. Sych
doaj +1 more source
Research on Etiological aspects of Dual Pathology [PDF]
, 2010 Introducción: Es importante evaluar la interacción entre los antecedentes psicopatológicos familiares (AF), la dinámica familiar (DF), los trastornos de conducta, los trastornos por uso de sustancias y los trastornos de personalidad (TP).
Barea, Juan +6 more
core +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
The Relationship between Anxiety and Depressive Symptoms and Substance Misuse (in Terms of Marijuana, Illicit Drugs, Tobacco, and Alcohol) in College Students [PDF]
, 2020 The Relationship between Anxiety and Depressive Symptoms and Substance Misuse (in Terms of Marijuana, Illicit Drugs, Tobacco, and Alcohol) in College Students Devin Singh, Depts. of Psychology and Chemistry, with Dr. Sally Kuo and Dr.
Singh, Devin
core +1 more source
Substance P and neprilysin in chronic pancreatitis [PDF]
, 2012 Background/Aims: We aimed to analyze substance P (SP) and neprilysin (NEP), the membrane metallopeptidase that degrades SP, in chronic pancreatitis (CP).
Bassi, Claudio +8 more
core +1 more source