Results 81 to 90 of about 676,730 (305)

Treating substance abuse is not enough: Comorbidities in consecutively admitted female prisoners

, 2015
Publisher Copyright: © 2015 Elsevier Ltd.Introduction: Several studies have pointed to high rates of substance use disorders among female prisoners. The present study aimed to assess comorbidities of substance use disorders with other mental disorders in
Ströhle, Andreas, Mir, J, Mundt, AP, Mir, Jan, Stroehle, A, Kastner, Sinja, Konrad, N, Konrad, Norbert, Priebe, S, Mundt, Adrian P., Kastner, S, Priebe, Stefan   +11 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Predictors of retention in the ‘voluntary’ and ‘quasi-compulsory’ treatment of substance dependence in Europe [PDF]

, 2011
Background: Policies and practices related to the quasi-compulsory treatment (QCT) of substance-dependent offenders are currently implemented in many countries, despite the absence of reliable knowledge about significant predictors of treatment retention.
Michael Schaub, Oeuvray, K., Haug, Severin; https://orcid.org/, Werdenich, W, Haug, Severin, Irene Puppo, Oeuvray, K, Severin Haug, Stevens, A., Schaub, Michael, Santa Maria, A, Schaub, Michael P; https://orcid.org/, Neil Hunt, Kerrie Oeuvray, Trinkl, B, Santa Maria, Alberto, Alberto Santa Maria, Berto, D., Puppo, Irene, Werdenich, Wolfgang, McSweeney, Tim, Schaub, M., Kerschl, V., Werdenich, W., Oeuvray, Kerrie, Kerschl, V, Viktoria Kerschl, Kerschl, Viktoria, Uchtenhagen, Ambros, Daniele Berto, Ambros Uchtenhagen, Stevens, Alex, Hunt, Neil, Haug, S., Berto, Daniele, Berto, D, Tim McSweeney, Wolfgang Werdenich, Uchtenhagen, A., Hunt, N, Trinkl, Barbara, Santa Maria, A., Stevens, A, Alex Stevens, Barbara Trinkl, Puppo, I., Puppo, I, Trinkl, B., Hunt, N., McSweeney, T   +49 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

SUBSTANCE ABUSE TREATMENT: WHAT DO WE KNOW? AN ECONOMIST’S PERSPECTIVE [PDF]

The substance abuse treatment literature has basically dealt with four important questions: 1) Is treatment effective? 2) Are all programs equally effective? 3) why do programs differ in their effectiveness?
Matilde P. Machado
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients

Annals of Medicine
Purpose To evaluate levels of 3 tear-soluble neuropeptides in dry eye patients and to identify the correlations with clinical signs and symptoms.Methods A total of 16 dry eye patients and 12 healthy volunteers were enrolled.
Yirou Zhang, Hong Zhang, Xingyu Zhu, Han Ye, Kan Yang, Xujiao Zhou, Jiaxu Hong   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source