Results 91 to 100 of about 2,092,443 (297)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Improved Quality of Life Following Addiction Treatment Is Associated with Reductions in Substance Use [PDF]
, 2019 People seeking treatment for substance use disorders (SUD) ultimately aspire to improve their quality of life (QOL) through reducing or ceasing their substance use, however the association between these treatment outcomes has received scant research ...
Allsop, Steve +8 more
core +2 more sources
Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients
Annals of MedicinePurpose To evaluate levels of 3 tear-soluble neuropeptides in dry eye patients and to identify the correlations with clinical signs and symptoms.Methods A total of 16 dry eye patients and 12 healthy volunteers were enrolled.
Yirou Zhang +6 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Antimitotic action of cornin as a biologically active polypeptide. I. Biochemical properties of cornin [PDF]
, 1965 We succeeded in the extraction of a substance from beef cornea and rabbit muscle, that markedly inhibits mitosis of sea urchin eggs. The substance extracted from beef cornea is non-dialysable and it can be separated into three fractions by DEAE-cellulose
Murakami, Tetuhide H., Nisida, Isamu
core +1 more source
Endocrine Regulations, 2019 Objective. The aim of the present study was to demonstrate the spatial relationship between the c-Fos immunoreactive cells elicited by an acute treatment with neuroleptics including amisulpride (AMI), olanzapine (OLA), quetiapine (QUE), and aripiprazole (
Kiss Alexander, Osacka Jana
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Experimental and clinical studies on an anti-tumor activity of OX substance [PDF]
, 1964 1) OX substance showed marked cytotoxicities in cell suspension culture of Yoshida sarcoma cells, celothelioma cells, and Ehrlich ascites tumor cells. It has become clear that the cytotoxicities have two aspects; one, nuclear shrinkage and karyolisis as ...
Ofuji, Tadashi
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Relationship of Substance P with the Degree of Atopic Dermatitis Severity
Clinical, Cosmetic and Investigational Dermatology, 2021 Deryne Anggia Paramita, Khairina Nasution, Nova Zairina Lubis Department of Dermatology and Venereology, Faculty of Medicine, Universitas of Sumatera Utara, Sumatera Utara, 20155, IndonesiaCorrespondence: Deryne Anggia Paramita Email deryne.anggia@usu.ac.
Paramita DA, Nasution K, Lubis NZ
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source