Results 1 to 10 of about 440 (147)
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors [PDF]
Current Oncology, 2021 Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 receptor/
Julian Kolorz +13 more
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Neurokinin-1 receptor activation in globus pallidus [PDF]
Frontiers in Neuroscience, 2009 The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine
Lei Chen +4 more
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Neurokinin 1 Receptor Antagonists for Pruritus [PDF]
Drugs, 2021 Pruritus, commonly known as itch, is a very common symptom in numerous dermatological disorders and systemic diseases. It can manifest as acute, or when lasting longer than 6 weeks, it is considered chronic and can lead to significant distress and reduced quality-of-life of those suffering.
Majid Alam +3 more
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Frontiers in Pharmacology, 2022 Situational syncope, which includes rectally mediated reflexes, is defined as syncope induced by a specific situation. Its pathogenesis generally involves disorders of the autonomic nervous system.
Kentaro Kurogochi +3 more
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A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor‐mediated apoptosis in glioblastomas [PDF]
Journal of Neurochemistry, 2009 AbstractPrevious studies have shown that neurokinin 1 receptor (NK1R) occurs naturally in human glioblastomas and its stimulation causes cell proliferation. In the present study we show that stimulation of NK1R in human U373 glioblastoma cells by substance P increases Akt phosphorylation by 2.5‐fold, with an EC50of 57 nM.
Toshimasa, Akazawa +6 more
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Neurokinin-1 Receptor Antagonists against Hepatoblastoma [PDF]
Cancers, 2019 Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed.
Miguel Muñoz +2 more
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In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
Pharmaceutics, 2022 Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed.
Paweł K. Halik +5 more
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Cell & Bioscience, 2023 Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility,
Lan Phuong Nguyen +11 more
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Molecules, 2020 Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik +5 more
doaj +1 more source
Neurokinin 1 receptor expression in the rat retina [PDF]
The Journal of Comparative Neurology, 1997 Tachykinin (TK) peptides influence neuronal activity in the inner retina of mammals. The aim of this investigation was to determine the cellular localization of the neurokinin 1 receptor (NK1), whose preferred ligand is the TK peptide substance P (SP), in the rat retina.
CASINI, GIOVANNI +3 more
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