Results 1 to 10 of about 12,085 (139)
Neurokinin 1 Receptor Antagonists for Pruritus. [PDF]
Drugs, 2021 Pruritus, commonly known as itch, is a very common symptom in numerous dermatological disorders and systemic diseases. It can manifest as acute, or when lasting longer than 6 weeks, it is considered chronic and can lead to significant distress and reduced quality-of-life of those suffering.
Alam M +3 more
europepmc +4 more sources
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors. [PDF]
Curr Oncol, 2021 Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 receptor/ substance P complex plays an important role in cancer and proved to be a promising target. However,
Kolorz J +13 more
europepmc +6 more sources
Neurokinin-1 Receptor Inhibition and Cough. [PDF]
Am J Respir Crit Care Med, 2021 Turner RD, Birring SS.
europepmc +4 more sources
Advances in the research and application of neurokinin-1 receptor antagonists. [PDF]
J Zhejiang Univ Sci BRecently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK ...
Hong X, Ma J, Zheng S, Zhao G, Fu C.
europepmc +3 more sources
A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor‐mediated apoptosis in glioblastomas [PDF]
Journal of Neurochemistry, 2009 AbstractPrevious studies have shown that neurokinin 1 receptor (NK1R) occurs naturally in human glioblastomas and its stimulation causes cell proliferation. In the present study we show that stimulation of NK1R in human U373 glioblastoma cells by substance P increases Akt phosphorylation by 2.5‐fold, with an EC50of 57 nM.
Toshimasa, Akazawa +6 more
openaire +2 more sources
Neurokinin-1 Receptor Antagonists against Hepatoblastoma [PDF]
Cancers, 2019 Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed.
Miguel Muñoz +2 more
openaire +5 more sources
Neurokinin-1 receptor activation in globus pallidus [PDF]
Frontiers in Neuroscience, 2009 The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine the electrophysiological effects of neurokinin-1 receptor activation in globus pallidus, whole-cell
Lei Chen +4 more
openaire +3 more sources
Neurokinin 1 receptor expression in the rat retina [PDF]
The Journal of Comparative Neurology, 1997 Tachykinin (TK) peptides influence neuronal activity in the inner retina of mammals. The aim of this investigation was to determine the cellular localization of the neurokinin 1 receptor (NK1), whose preferred ligand is the TK peptide substance P (SP), in the rat retina.
CASINI, GIOVANNI +3 more
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Neurokinin-1 Receptor Blockade and Murine Lung Tumorigenesis [PDF]
American Journal of Respiratory and Critical Care Medicine, 2006 Abstract Rationale Analogous to the adenoma-carcinoma sequence in the colon, it has been proposed that adenocarcinoma (AC) in the lung arises from adenomatous hyperplasia that progresses through atypical adenomatous hyperplasia to AC.
LUCATTELLI, M. +4 more
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Activation of neurokinin‐1 receptors up‐regulates substance P and neurokinin‐1 receptor expression in murine pancreatic acinar cells [PDF]
Journal of Cellular and Molecular Medicine, 2012 AbstractAcute pancreatitis (AP) has been associated with an up‐regulation of substance P (SP) and neurokinin‐1 receptor (NK1R) in the pancreas. Increased SP‐NK1R interaction was suggested to be pro‐inflammatory during AP. Previously, we showed that caerulein treatment increased SP/NK1R expression in mouse pancreatic acinar cells, but the effect of SP ...
Koh, Yung-Hua +2 more
openaire +2 more sources