Results 21 to 30 of about 440 (147)

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Nature Communications, 2019
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically ...
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun   +6 more
doaj   +1 more source

Medullary tachykinin precursor 1 neurons promote rhythmic breathing

eLife, 2023
Rhythmic breathing is generated by neural circuits located in the brainstem. At its core is the preBötzinger Complex (preBötC), a region of the medulla, necessary for the generation of rhythmic breathing in mammals.
Jean-Philippe Rousseau, Andreea Furdui, Carolina da Silveira Scarpellini, Richard L Horner, Gaspard Montandon   +4 more
doaj   +1 more source

Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Molecular Pain, 2007
Background Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it is unclear whether SP regulates its own release from primary sensory neurons.
Arihiro Koji, Li Yu-Sang, Tang He-Bin, Nakata Yoshihiro   +3 more
doaj   +1 more source

Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights

International Journal of Inflammation, 2010
Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved.
Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia   +3 more
doaj   +1 more source

Autocrine regulation of human sperm motility by tachykinins

Reproductive Biology and Endocrinology, 2010
Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M, Ravina Cristina G, Subiran Nerea, Cejudo-Román Antonio, Fernández-Sánchez Manuel, Irazusta Jon, Garrido Nicolas, Candenas Luz   +7 more
doaj   +1 more source

Expression of substance P and neurokinin-1 receptor in nasopharyngeal carcinoma and their clinical significance

Di-san junyi daxue xuebao, 2020
Objective To investigate the expression of substance P (SP) and its receptor, neurokinin-1 receptor (NK-1R), in nasopharyngeal carcinoma (NPC) tissues and their correlation with the clinicopathological parameters of the patients.
ZHANG Yu, YANG Yucheng, YANG Kun, FENG Dandan, HUANG Jiangju   +4 more
doaj   +1 more source

Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow. [PDF]

PLoS ONE, 2016
Substance P is released in painful and inflammatory conditions, affecting both peripheral processes and the central nervous system neurokinin 1 (NK1) receptor.
Clas Linnman, Ciprian Catana, Kurt Svärdsudd, Lieuwe Appel, Henry Engler, Bengt Långström, Jens Sörensen, Tomas Furmark, Mats Fredrikson, David Borsook, Magnus Peterson   +10 more
doaj   +1 more source

Neurokinin-1 Receptor Regulation of Fibroblast Phenotype and Function

Receptors
Injury to tissue induces the normal wound healing process to repair damage. This is a normal and critical response developed by the body to maintain short-term organ function, and therefore, survival.
Scott P. Levick
doaj   +1 more source

Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord. [PDF]

PLoS ONE, 2013
Substance P (SP) and its receptor, the neurokinin 1 receptor (NK1R), play important roles in transmitting and regulating somatosensory nociceptive information.
Ming-Ming Zhang, Wei Ji, Li-Yu Pei, Wen Wang, Tao Chen, Wei Wang, Hui Li, Ting Zhang, Sheng-Xi Wu, Yun-Qing Li   +9 more
doaj   +1 more source

Activation of neurokinin‐1 receptors up‐regulates substance P and neurokinin‐1 receptor expression in murine pancreatic acinar cells [PDF]

Journal of Cellular and Molecular Medicine, 2012
AbstractAcute pancreatitis (AP) has been associated with an up‐regulation of substance P (SP) and neurokinin‐1 receptor (NK1R) in the pancreas. Increased SP‐NK1R interaction was suggested to be pro‐inflammatory during AP. Previously, we showed that caerulein treatment increased SP/NK1R expression in mouse pancreatic acinar cells, but the effect of SP ...
Koh, Yung-Hua, Moochhala, Shabbir, Bhatia, Madhav   +2 more
openaire   +2 more sources