Results 211 to 220 of about 21,551,551 (367)

The effect of substance P on the acetylcholine release from the guinea-pig ileum

, 1983
Takanori Ikeda, Osamu Yagasaki, Iwao Yanagiya   +2 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Exercise-Dependent effects of substance P deficiency on joint degeneration and inflammation in a surgical mouse model of osteoarthritis. [PDF]

Arthritis Res Ther
Pann P, Kalke P, Maier V, Schäfer N, Clausen-Schaumann H, Schilling AF, Grässel S.   +6 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Anti-Metastatic Effects of Aprepitant on Glioblastoma Cells: Targeting the Substance P/Neurokinin-1 Pathway. [PDF]

Cancer Med
Engür-Öztürk S, Kaya-Tilki E, Dikmen M.   +2 more
europepmc   +1 more source

Intradermal substance P as a challenge agent in healthy individuals. [PDF]

Clin Transl Sci, 2023
Ten Voorde W, Akinseye C, Abdisalaam I, Wind S, Klarenbeek N, Bergmans M, van Doorn M, Rissmann R, Kaur R, Hotee S, Foster K, Nair A, Fortunato L, Macphee C, Mole S, Baumann K, Brigandi R.   +16 more
europepmc   +1 more source

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

Journal of Clinical Investigation, 1994
M. Ziche, L. Morbidelli, E. Masini, S. Amerini, H. Granger, C. Maggi, P. Geppetti, F. Ledda   +7 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Predictive Value of Substance P for Pulmonary Infection in Patients With Acute Cerebral Infarction During Hospitalization. [PDF]

J Clin Neurol
Jiang L, Yuan Q, Guo X, Zhou B, Zhang Y, Li L, Yan C, Zhang Y, Ma Y.   +8 more
europepmc   +1 more source

ELEVATED GLUCOSE AND FATTY ACID LEVELS IMPAIR SUBSTANCE P-INDUCED DERMAL MICROVASCULAR ENDOTHELIAL CELL MIGRATION AND PROLIFERATION IN AN AGAROSE GEL MODEL SYSTEM

, 2009
Qiang Wang, Lara A. Muffley, Kyla Hall, Marie Chase, Nicole S. Gibran   +4 more
openalex   +2 more sources