Results 251 to 260 of about 676,730 (305)
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Nature, 1976
SUBSTANCE P (SP)1 has long been known to have marked effects on the central nervous system (CNS). Lembeck2 suggested that SP might be a transmitter of primary sensory impulses, an hypothesis supported by subsequent investigators3,4. Early work on SP was carried out using natural material, which unless highly purified, is known to be contaminated with ...
J M, Stewart +5 more
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SUBSTANCE P (SP)1 has long been known to have marked effects on the central nervous system (CNS). Lembeck2 suggested that SP might be a transmitter of primary sensory impulses, an hypothesis supported by subsequent investigators3,4. Early work on SP was carried out using natural material, which unless highly purified, is known to be contaminated with ...
J M, Stewart +5 more
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Substance P and antinociception
Peptides, 1983Substance P (SP)-induced antinociception is still a topic of controversy. Some investigators have failed to see an antinociceptive effect of SP, particularly following intraperitoneal administration. In the present experiments SP induced significant hot plate antinociception in male mice, following intraperitoneal administration.
M E, Hall, J M, Stewart
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Radioimmunoassay for Substance P
Nature New Biology, 1973IN 1931, Von Euler and Gaddum demonstrated the presence of a substance in extracts of brain and of intestine that causes contraction of isolated intestinal muscle in vitro and vasodilatation and hypotension in vivo1. These effects occur in the presence of atropine and hence are independent of acetylcholine.
D, Powell +4 more
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Nature New Biology, 1971
SUBSTANCE P has been synthesized by the solid-phase procedure of Merrifield1,2 according to the sequence H-Arg-Pro-LysPro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 reported in the previous letter.
G W, Tregear +4 more
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SUBSTANCE P has been synthesized by the solid-phase procedure of Merrifield1,2 according to the sequence H-Arg-Pro-LysPro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 reported in the previous letter.
G W, Tregear +4 more
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General and Comparative Endocrinology, 1980
Abstract Immunoreactive substance P (ISP) was measured by radioimmunoassay in acid-acetone tissue extracts in representative species of invertebrates (phyla Coelenterata and Mollusca) and of non-mammalian vertebrates (Elasmobranchii, Teleostei, Amphibia, Reptilia, Aves).
T, Creagh +4 more
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Abstract Immunoreactive substance P (ISP) was measured by radioimmunoassay in acid-acetone tissue extracts in representative species of invertebrates (phyla Coelenterata and Mollusca) and of non-mammalian vertebrates (Elasmobranchii, Teleostei, Amphibia, Reptilia, Aves).
T, Creagh +4 more
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Substance P and substance P receptors in bone and gingival tissues
Medical Electron Microscopy, 2001Substance P (SP) is an important member of the tachykinin family of neuropeptides, which work as neurotransmitters or neuromodulators. Recent advances in the analysis of SP receptors, particularly the neurokinin-1 receptors (NK1-Rs) that have high affinity for SP, have demonstrated that they are distributed not only in the cells of the neuronal or ...
T, Goto, M A, Kido, T, Yamaza, T, Tanaka
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Differentiation of substance P and physalaemin
Naunyn-Schmiedebergs Archiv f�r Pharmakologie, 19691. The physical and chemical properties of substance P (extracted from bovine brain) and physalaemin were investigated by several methods. 2. During paper electrophoresis at pH 4.95 substance P migrates towards the cathode, physalaemin remains at the starting point. 3.
F. Geipert, F. Lembeck, B. Sprössler
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Clinics in Dermatology, 1991
Abstract For centuries people have known that the seeds and membranes of certain species of plants of the nightshade family, notably capsicum, possess a principle that produces intense erythema, pain, and inflammation when applied to skin or mucous membrane.
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Abstract For centuries people have known that the seeds and membranes of certain species of plants of the nightshade family, notably capsicum, possess a principle that produces intense erythema, pain, and inflammation when applied to skin or mucous membrane.
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