Results 51 to 60 of about 676,730 (305)

Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells

Folia Neuropathologica, 2020
A neuropeptide, Substance P (SP), has mitogenic action in many types of cancer cells mediated via the neurokinin-1 receptor (NK1R). Small molecular NK1R antagonists have been frequently shown to possess anticancer activity both in vivo and in vitro, but ...
Joanna Matalińska, Agnieszka Świć, Piotr Lipiński, Aleksandra Misicka   +3 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Comparing outcomes of ‘voluntary’ and ‘quasi-compulsory’ treatment of substance dependence in Europe [PDF]

, 2010
Aim: This study evaluates quasi-compulsory drug treatment (QCT) arrangements for substance-dependent offenders receiving treatment instead of imprisonment in comparison to voluntary treatment within five European countries.
Oeuvray, K., Werdenich, W., Werdenich, W, Oeuvray, Kerrie, Kerschl, V, Oeuvray, K, Kerschl, Viktoria, Uchtenhagen, Ambros, Stevens, A., Schaub, Michael, Santa Maria, A, Schaub, Michael P; https://orcid.org/, Stevens, Alex, Trinkl, B, Hunt, Neil, Santa Maria, Alberto, Berto, Daniele, Berto, D, Uchtenhagen, A., Berto, D., Hunt, N, Trinkl, Barbara, Santa Maria, A., Puppo, Irene, Werdenich, Wolfgang, Stevens, B, McSweeney, Tim, Schaub, M., Puppo, I., Puppo, I, Kerschl, V., Trinkl, B., Hunt, N., McSweeney, T   +33 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline

Beilstein Journal of Organic Chemistry
A new total synthesis of the β-carboline alkaloid brevicarine is disclosed. The synthesis was carried out starting from an aromatic triflate key intermediate, allowing the introduction of various substituents into position 4 of β-carboline by cross ...
Benedek Batizi, Patrik Pollák, András Dancsó, Péter Keglevich, Gyula Simig, Balázs Volk, Mátyás Milen   +6 more
doaj   +1 more source

Comparison of aprepitant versus ondansetron for prevention of postoperative nausea and vomiting: A systematic review and meta-analysis with trial sequential analysis

Indian Journal of Anaesthesia
Background and Aims: Postoperative nausea and vomiting (PONV) is a common complication after surgery. Preventing PONV in high-risk patients often requires a multimodal approach combining antiemetic drugs with diverse mechanisms.
Madhusudan P. Singh, Meenalotchini P. Gurunthalingam, Ayushee Gupta, Juhi Singh   +3 more
doaj   +1 more source

GA&HA-Modified Liposomes for Co-Delivery of Aprepitant and Curcumin to Inhibit Drug-Resistance and Metastasis of Hepatocellular Carcinoma [Corrigendum]

International Journal of Nanomedicine, 2022
Li Y, Wu J, Lu Q, et al. Int J Nanomedicine. 2022;17:2559-2575. The authors have advised that an error was made during the preparation of the Masson trichromatic staining tumor tissue images shown in Figure 7G on page 2570.
Li Y, Wu J, Lu Q, Liu X, Wen J, Qi X, Liu J, Lian B, Zhang B, Sun H, Tian G   +10 more
doaj  

Substance use among populations displaced by conflict: a literature review. [PDF]

, 2011
: This paper reviews the literature on substance use among populations displaced by conflict. Of the 17 publications presenting primary data retained for review, all consider populations in or recovering from protracted conflict, the majority (10) in non-
Ezard, Nadine, Nadine Ezard, Ezard, N
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

The effect of aprepitant, a neurokinin-1 receptor antagonist, on epileptiform activity in the penicillin model of epilepsy

Medicine Science
Substance P (SP) is a peptide neurotransmitter that plays a role in pain transmission, stress, inflammation, and emesis through neurokinin-1 receptor (NK-1R).
Selma Cirrik, Eli̇f Dogan, Ali̇ Aslan, Ni̇yazi̇ Tasci   +3 more
doaj   +1 more source