Results 91 to 100 of about 673,739 (304)

Public spending for illegal drug and alcohol treatment in hospitals: an EU cross-country comparison [PDF]

, 2014
Background: In view of the current economic crisis and the resulting austerity measures being implemented by governments across Europe, public expenditure for substance abuse treatment has increasingly become a subject of discussion.
Christiaens, Johan, Lievens, Delfine, Vander Laenen, Freya   +2 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

ASSISTANCE TO ADOLESCENTS WHO USE PSYCHOACTIVE SUBSTANCES: ROLE OF THE PSYCHOSOCIAL CARE CENTER

Cogitare Enfermagem, 2017
The present study aimed to gain insight into the role of a Psychosocial Care Center for Users of Alcohol and other Drugs (CAPS AD) that assists adolescents who usepsychoactive substances, from the views of the professionals of Guardianship Councils and ...
Bruna Rios Paim, Daniele Dalla Porta, Diana Mara Sarzi, Mirela Frantz Cardinal, Daiana Foggiato de Siqueira, Amanda de Lemos Mello, Marlene Gomes Terra   +6 more
doaj   +1 more source

La investigación biomédica sobre abuso de sustancias a través de la base de datos Medline (2006-2010) [PDF]

, 2015
El Abuso de sustancias es uno de los principales problemas sociales y de salud pública a escala mundial. Este estudio analiza la investigación científica sobre los trastornos relacionados con sustancias generado a lo largo del período 2006-2010 así como ...
Agulló Calatayud, Víctor, Fernandes, Luis, González Alcaide, Gregorio, Pinto, Marta   +3 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Sexual Orientation Differences in the Relationship Between Victimization and Hazardous Drinking Among Women in the National Alcohol Survey [PDF]

, 2013
This study examined relationships between past experiences of victimization (sexual abuse and physical abuse in childhood, sexual abuse and physical abuse in adulthood, and lifetime victimization) and hazardous drinking among sexual minority women ...
Drabble, Laurie A, Hughes, T. L., Korcha, R. A., Lown, A. E., Trocki, K. F.   +4 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Decreasing brain activity caused by acute administration of ketamine and alcohol – A randomized, controlled, observer-blinded experimental study

Frontiers in Pharmacology
IntroductionSubstance abuse is a major public health problem. In recent years, ketamine, which is a parenteral anesthetic, has been consumed increasingly as an illicit drug together with alcohol, although little is known of how this association alters ...
Luan Oliveira Ferreira, Luan Oliveira Ferreira, Esther Padilha da Silveira, Clarissa A. Paz, Maria K. Otake Hamoy, Gabriela B. Barbosa, Murilo F. Santos, Raína M. Conceição, Anthony Lucas G. Amaral, Karina Dias Resende, Dielly Catrina Favacho Lopes, Moisés Hamoy   +11 more
doaj   +1 more source

Development of an integrated cognitive behavioral therapy for anxiety and opioid use disorder: Study protocol and methods [PDF]

, 2017
Opioid use disorder is a highly disabling psychiatric disorder, and is associated with both significant functional disruption and risk for negative health outcomes such as infectious disease and fatal overdose. Even among those who receive evidence-based
Barlow, David H., Fitzmaurice, Garrett M., Greenfield, Shelly F., McHugh, R. Kathryn, Votaw, Victoria R., Weiss, Roger D.   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source