Results 51 to 60 of about 321,536 (302)

Pattern of psychoactive substance use by students - Ribeirão Preto

Saúde em Debate
The aim was to analyze the use of psychoactive substances among students in their final year of middle school and high school in Ribeirão Preto and reflect on the pattern of psychoactive drug use based on epidemiological studies conducted over the last ...
Margarita Antonia Villar Luis, Sandra Cristina Pillon, Moacyr Lobo da Costa Junior, Paulo Sérgio Ferreira, Jaqueline Queiroz de Macedo   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Risk factors for incidence and persistence of disability in chronic major depression and alcohol use disorders: longitudinal analyses of a population-based study [PDF]

, 2014
BackgroundMajor depression and alcohol use disorders are risk factors for incidence of disability. However, it is still unclear whether a chronic course of these health conditions is also prospectively associated with incidence of disability.
José Luis Ayuso-Mateos, Ayuso-Mateos, J., Cieza, A., Alarcos Cieza, Chatterji, S., Cabello, M., Caballero, F., Somnath Chatterji, María Cabello, Francisco Félix Caballero   +9 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Vocational Rehabilitation for Individuals With Substance-Related Disorders

Iranian Rehabilitation Journal, 2019
Objectives: The present review study aimed at investigating the vocational rehabilitation of individuals with drug dependence disorders.  Methods: Based on the research method, a comprehensive search was conducted in the following databases: PubMed ...
Younes Doostian, Bahman Bahmani, Ali Farhoudian, Manoochehr Azkhosh, Mohammad Saeed Khanjani   +4 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Scaling up services for mental and neurological disorders in low-resource settings. [PDF]

, 2009
Mental and neurological disorders (MNDs) account for a large, and growing, burden of disease in low- and middle-income countries. Most people do not have access to even basic health care for these disorders.
Vikram Patel, Desai, Rajnanda, Patel, Vikram, Goel, Digvijay Singh, Digvijay Singh Goel, Rajnanda Desai   +5 more
core   +1 more source

Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study. [Elektronisk resurs]

, 2017
Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD).
Långström, N,, Lichtenstein, P,, Larsson, H,, Almqvist, C, Butwicka, A,, Lundström, S, Serlachius, E,, Frisén, L,   +7 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source