Results 61 to 70 of about 321,536 (302)

O primeiro contato com as drogas: análise do prontuário de mulheres atendidas em um serviço especializado

Saúde em Debate
O estudo objetivou caracterizar e compreender o contexto em que se dá o primeiro contato de mulheres com problemas relacionados ao uso de substâncias psicoativas que procuraram atendimento em um serviço especializado em álcool e outras drogas.
Divane de Vargas, Janaina Soares, Erika Leon, Caroline Figueira Pereira, Talita Dutra Ponce   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism

, 2008
These practice guidelines for the biological treatment of substance use disorders were developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal during the development of these guidelines was
Berglund, Mats, Johnson, BA, Kranzler, HR, Hesselbrock, V, the WFSBP Task Force on Treatment Guidelines for Substance Use Disorders, .reatment Guidelines for Substance Use Disorders, Soyka, M, Gorelick, D, Moller, H-J, Berglund, Mats,   +8 more
core   +1 more source

Prevalence of Alcohol Consumption and Hazardous Drinking, Tobacco and Drug use in urban Tanzania, and Their associated Risk Factors. [PDF]

, 2009
Evidence suggests substance abuse in Tanzania is a growing public health problem. A random sample of 899 adults aged 15-59 in two urban sites of differing levels of poverty surveyed alcohol, tobacco and illicit substance use.
Rachel Jenkins, Bethany White, Jenkins, Rachel, Joseph Mbatia, Singleton, Nicola, White, Bethany, Mbatia, Joseph, Nicola Singleton   +7 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Non-Substance-Related Disorders: Gambling disorder and internet addiction

, 2014
Behavioral addictions are highly prevalent and have a major individual and societal impact. Moreover, given the availability and increase of potentially addictive activities in our societal development (e.g.
Wölfling, Klaus, Dom, Geert, Bischof, A., Leménager, Tagrid, Thon, Natasha, Moggi, Franz, Tagrid Leménager, Bischof, Anja, Geert Dom, Anja Bischof, Rumpf, H.J., Thon, N., Klaus Wölfling, Hans-Jürgen Rumpf, Wolfling, K., Franz Moggi, Natasha Thon, Lemenager, T., Moggi, F., Friedrich Martin Wurst, Rumpf, Hans-Jürgen, Wurst, Friedrich Martin   +21 more
core   +1 more source

Bullying involvement and substance use among Brazilian adolescent students

Revista Panamericana de Salud Pública, 2018
Objective. Although bullying involvement has been associated with adolescent substance use, most of this evidence comes from high-income countries. Little is known about substance use among perpetrator-victims in low- and middle-income countries.
Natalia Woolley, James Macinko
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Addiction Phenomenology In Substance Use And Non-Substance Use Disorders

, 2008
There is growing research evidence and public concern over the burgeoning of disorders which share common features with substance addictions. In order to investigate the presence and role of addiction features in disorders outside of substance addictions,
McLachlan, Andre David
core