Results 91 to 100 of about 270,199 (315)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Borderline personality disorder and substance use disorders: an updated review

Borderline Personality Disorder and Emotion Dysregulation, 2018
For decades, clinicians and researchers have recognized that borderline personality disorder (BPD) and substance use disorders (SUDs) are often diagnosed within the same person (e.g., (Gunderson JG.
Timothy J. Trull, Lindsey K. Freeman, Tayler J. Vebares, Alexandria M. Choate, Ashley C. Helle, Andrea M. Wycoff   +5 more
doaj   +1 more source

Substance Use Disorder in Early Midlife: A National Prospective Study on Health and Well-Being Correlates and Long-Term Predictors

, 2015
This study used national multicohort panel data from the Monitoring the Future study ( N = 25,536 from senior year classes 1977–1997 followed up to the age of 35 years in 1994–2014) to examine how early midlife (age 35 years) alcohol use disorder (AUD ...
Julie Maslowsky, John E. Schulenberg, Patrick M. O'malley, Megan E. Patrick, Jennifer L. Maggs, Patrick M. O’Malley, Deborah D. Kloska   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy

Frontiers in Pharmacology, 2023
Scott John, David R. Walwyn, Kathryn DeFea, Tim G. Hales, Wendy Walwyn   +4 more
doaj   +1 more source

Sociodemographic Determinants, Early Maladaptive Schemas, and Childhood Traumas Increase the Risk of Substance and/or Alcohol Use in Women: A Case–Control Study

Addicta: The Turkish Journal on Addictions
In this case–control study, to determine the effect of early maladaptive schemas and childhood traumas under risk of alcohol and substance use in women was aimed.
Cinar Ozgu, Ergin Isil
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Associations between past-year receipt of government assistance, Medicaid, and substance use treatment utilization among adults with substance use disorder in the United States

Addictive Behaviors Reports
Aim: Most people who need substance use disorder (SUD) treatment do not receive care, often due to costs and lack of health insurance. We investigated whether receipt of government assistance and Medicaid among people with SUDs was associated with past ...
Sarah Gutkind, Morgan M. Philbin, Emilie Bruzelius, Silvia S. Martins, Pia M. Mauro   +4 more
doaj   +1 more source

Governor's Council on Substance Use Disorder - January 16, 2024

Downloaded from: https://www.nj.gov/gcsud/gcsud/agendas-minutes/ Agenda and minutes are in separate ...
New Jersey. Governor's Council on Substance Use Disorder
core  

ADHD IN ADULTS: COMORBODITY WITH BIPOLAR DISORDER AND SUBSTANCE ABUSE

, 2011
ADHD is characterized by a continuous history of hyperactivity, forgetfulness, distractibility, impulsiveness and/or inattention, starting from the early childhood and at a more severe extent than whatever may be usual in peers.
CERAUDO, GIUSEPPE
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