Results 101 to 110 of about 639,012 (296)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sociodemographic Determinants, Early Maladaptive Schemas, and Childhood Traumas Increase the Risk of Substance and/or Alcohol Use in Women: A Case–Control Study

Addicta: The Turkish Journal on Addictions
In this case–control study, to determine the effect of early maladaptive schemas and childhood traumas under risk of alcohol and substance use in women was aimed.
Cinar Ozgu, Ergin Isil
doaj   +1 more source

Borderline personality disorder and substance use disorders: an updated review

Borderline Personality Disorder and Emotion Dysregulation, 2018
For decades, clinicians and researchers have recognized that borderline personality disorder (BPD) and substance use disorders (SUDs) are often diagnosed within the same person (e.g., (Gunderson JG.
Timothy J. Trull, Lindsey K. Freeman, Tayler J. Vebares, Alexandria M. Choate, Ashley C. Helle, Andrea M. Wycoff   +5 more
doaj   +1 more source

The Experience of Intimate Partner Violence Among Pregnant Women Seeking Treatment for Opioid Use Disorder [PDF]

, 2020
Introduction: Intimate partner violence (IPV) is a major health issue among those with substance use disorder. A history of partner violence is associated with increased health problems and less improvement in treatment. The perinatal period is a time of
Abatemarco, PhD, MSW, Diane, Dewey, Julia   +1 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy

Frontiers in Pharmacology, 2023
Scott John, David R. Walwyn, Kathryn DeFea, Tim G. Hales, Wendy Walwyn   +4 more
doaj   +1 more source

Associations between past-year receipt of government assistance, Medicaid, and substance use treatment utilization among adults with substance use disorder in the United States

Addictive Behaviors Reports
Aim: Most people who need substance use disorder (SUD) treatment do not receive care, often due to costs and lack of health insurance. We investigated whether receipt of government assistance and Medicaid among people with SUDs was associated with past ...
Sarah Gutkind, Morgan M. Philbin, Emilie Bruzelius, Silvia S. Martins, Pia M. Mauro   +4 more
doaj   +1 more source

The classification of substance and behavioural addictions: A preliminary investigation [PDF]

, 2012
The term addiction has been used to refer to impaired control over substance use for several centuries however recently there has been a shift toward using this term in the context of non-substance use disorders, such as pathological gambling.
McLaughlan, Andre David, Starkey, Nicola J.   +1 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source