Results 81 to 90 of about 15,613,357 (259)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A pilot study to assess the feasibility and impact of a brief motivational intervention on problem drug and alcohol use in adult mental health inpatient units : study protocol for a randomized controlled trial [PDF]

, 2014
Background: Substance misuse in those with severe mental health problems is common and associated with poor engagement in treatment and treatment outcomes.
Hermine L Graham, Copello, Alex, Clarke, Latoya, Nick Freemantle, Kathryn Walsh, Birchwood, Max, Copello, Alexandre; id_orcid, Latoya Clarke, Emma Griffith, Walsh, Kathryn, Stefanidou, Chrysi A., Griffith, Emma, Paul McCrone, Graham, Hermine L., Freemantle, Nick, Arsal Rana, Alex Copello, Max Birchwood, Birchwood, M. J., Graham, Hermine, Birchwood, Maximillian, Rana, Arsal, Stefanidou, Chrysi A, McCrone, Paul, Chrysi A Stefanidou   +24 more
core   +2 more sources

Cariprazine in Bipolar Disorder and Substance Use: A Dual Approach to Treatment?

Pharmaceuticals
Bipolar disorder (BD) is characterized by recurrent episodes of mania, hypomania, and depression and is often complicated by comorbid substance use disorders (SUDs).
Simone Pardossi, Alessandro Cuomo, Despoina Koukouna, Mario Pinzi, Andrea Fagiolini   +4 more
doaj   +1 more source

Preventable hospitalizations among adult Medicaid beneficiaries with concurrent substance use disorders

Preventive Medicine Reports, 2015
Objective: We aim to examine the relationships between substance use disorders and preventable hospitalizations for Ambulatory Care Sensitive Conditions among adult Medicaid beneficiaries.
Kit Sang Leung, Joe Parks, James Topolski   +2 more
doaj   +1 more source

HIV and Substance Use Disorders

Infectious Disease Clinics of North America
Over 1.2 million Americans aged 13 years and older have been diagnosed with human immunodeficiency virus (HIV). While HIV incidence has been declining since 2017, the risk of HIV acquisition and transmission persists among persons who use drugs via injection drug use and unprotected sexual intercourse associated with substance use.
Lier, Audun J., Tarfa, Adati, Shenoi, Sheela V., Kuo, Irene, Springer, Sandra A.   +4 more
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Sociodemographic Determinants, Early Maladaptive Schemas, and Childhood Traumas Increase the Risk of Substance and/or Alcohol Use in Women: A Case–Control Study

Addicta: The Turkish Journal on Addictions
In this case–control study, to determine the effect of early maladaptive schemas and childhood traumas under risk of alcohol and substance use in women was aimed.
Cinar Ozgu, Ergin Isil
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Mentalization-based treatment for female patients with comorbid personality disorder and substance use disorder: A pilot study [PDF]

, 2017
Objectives: In this study, we investigated the feasibility of mentalization-based treatment (MBT) for patients with comorbid substance use disorder (SUD) and borderline personality disorder (BPD).
Morken, Katharina Teresa Enehaug, Binder, Per-Einar, Molde, Helge, Karterud, Sigmund, Arefjord, Nina   +4 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source