Results 81 to 90 of about 270,199 (315)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Preventable hospitalizations among adult Medicaid beneficiaries with concurrent substance use disorders

Preventive Medicine Reports, 2015
Objective: We aim to examine the relationships between substance use disorders and preventable hospitalizations for Ambulatory Care Sensitive Conditions among adult Medicaid beneficiaries.
Kit Sang Leung, Joe Parks, James Topolski   +2 more
doaj   +1 more source

Total and cause-specific standardized mortality ratios in patients with schizophrenia and/or substance use disorder [PDF]

, 2018
Individuals with schizophrenia or substance use disorder have a substantially increased mortality compared to the general population. Despite a high and probably increasing prevalence of comorbid substance use disorder in people with schizophrenia, the ...
Ystrøm, Eivind, Ragnar Nesvåg, Bramness, Jørgen Gustav, Anne Høye (5679836), Øyvind Næss, Nesvag, R, Ted Reichborn-Kjennerud, Reichborn-Kjennerud, T, Heiberg, Ina Heidi, Jørgen G. Bramness (5679833), Jacobsen, BK, Ted Reichborn-Kjennerud (721825), Christina M. Hultman (133603), Nesvåg, Ragnar, Ina H Heiberg, Anne Høye, Heiberg, IH, Hultman, CM, Høye, Anne, Ystrom, E, Ragnar Nesvåg (4954051), Eivind Ystrom (4278460), Bjarne K. Jacobsen (5679830), Christina M Hultman, Eivind Ystrom, Næss, Øyvind, Jørgen G Bramness, Naess, O, Bjarne K Jacobsen, Reichborn-Kjennerud, Ted, Hultman, Christina M, Hoye, A, Øyvind Næss (3917240), Bramness, JG, Jacobsen, Bjarne K., Ina H. Heiberg (5679827)   +35 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Six rapid assessments of alcohol and other substance use in populations displaced by conflict. [PDF]

, 2011
BACKGROUND: Substance use among populations displaced by conflict is a neglected area of public health. Alcohol, khat, benzodiazepine, opiate, and other substance use have been documented among a range of displaced populations, with wide-reaching health ...
Abandokoth Sakarati, David Macdonald, Adelekan, Moruf, Oppenheimer, Edna, Ezard, Nadine, Nadine Ezard, Ann Burton, Sakarati, Abandokoth, van Ommeren, Mark, Marian Schilperoord, Moruf Adelekan, Mark van Ommeren, Burton, Ann, Edna Oppenheimer, Macdonald, David, Schilperoord, Marian   +15 more
core   +1 more source