Results 61 to 70 of about 270,199 (315)

A pilot study to assess the feasibility and impact of a brief motivational intervention on problem drug and alcohol use in adult mental health inpatient units : study protocol for a randomized controlled trial [PDF]

, 2014
Background: Substance misuse in those with severe mental health problems is common and associated with poor engagement in treatment and treatment outcomes.
Hermine L Graham, Copello, Alex, Clarke, Latoya, Nick Freemantle, Kathryn Walsh, Birchwood, Max, Copello, Alexandre; id_orcid, Latoya Clarke, Emma Griffith, Walsh, Kathryn, Stefanidou, Chrysi A., Griffith, Emma, Paul McCrone, Graham, Hermine L., Freemantle, Nick, Arsal Rana, Alex Copello, Max Birchwood, Birchwood, M. J., Graham, Hermine, Birchwood, Maximillian, Rana, Arsal, Stefanidou, Chrysi A, McCrone, Paul, Chrysi A Stefanidou   +24 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mentalization-based treatment for female patients with comorbid personality disorder and substance use disorder: A pilot study [PDF]

, 2017
Objectives: In this study, we investigated the feasibility of mentalization-based treatment (MBT) for patients with comorbid substance use disorder (SUD) and borderline personality disorder (BPD).
Morken, Katharina Teresa Enehaug, Binder, Per-Einar, Molde, Helge, Karterud, Sigmund, Arefjord, Nina   +4 more
core   +1 more source

Disorders Due to Substance Use: Cannabis

, 2023
Cannabis has a long history of use for its psychoactive properties but is a relative newcomer to the Western world as an intoxicant. Nowadays, cannabis is widely used and it causes serious problems in a minority of those who use it. However, given the large numbers of people who use cannabis, that relative minority translates into a substantial ...
Cousijn, J., Compton, W.M., Levin, F.R.
openaire   +5 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cannabis use and mania symptoms : a systematic review and meta-analysis [PDF]

, 2014
Background: Whilst cannabis use appears to be a causal risk factor for the development of schizophrenia-related psychosis, associations with mania remain relatively unknown.
Marwaha, Steven, Singh, SP, Marwaha, S, Gilbert, E, Broome, Matthew, Singh, Swaran P, Broome, M, Gilbert, Eleanor, Singh, Swaran P., Broome, Matthew R., Gibbs, Melanie, Marwaha, Steven; id_orcid, Winsper, Catherine, Gibbs, M, Winsper, C   +14 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Substance use disorder risk assessment: positive emotional experiences with first time use and substance use disorder risk

Frontiers in Psychiatry
IntroductionSubstance Use Disorder (SUD) screening tools used in current practice are designed to identify SUD once patients have begun regular dangerous drug use.
Karen E. Arscott, Donna M. Eget, Maria C. Marcos, Brian J. Piper, Brian J. Piper   +4 more
doaj   +1 more source

Concerned parents, belligerent adolescent: Providing support to distressed parents

Indian Journal of Social Psychiatry, 2018
Societal changes have brought about transformation in the family dynamics in India. The youth of today is exposed to a wide variety of influences, and their tendency toward experimentation makes them vulnerable to get into unpleasant situations.
Siddharth Sarkar
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source