Results 51 to 60 of about 639,012 (296)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
BMC Psychiatry, 2018 Background Substance use disorder is an important public health problem and one of the major causes of disability worldwide. Substance use and criminal behavior are closely related and there is a significant association between substance misuse and crime,
Yimenu Yitayih +5 more
doaj +1 more source
Lifting the Burden of Addiction: Philanthropic Opportunities to Address Substance Use Disorders in the United States [PDF]
, 2015 Substance use disorders (SUDs), also known as substance abuse or addiction, affect an estimated 20 million or more adolescents and adults in the U.S. This guidance provides philanthropic funders with the tools & information to reduce immediate harm from ...
Cecily Wallman-Stokes +6 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Frontiers in Psychiatry, 2021 Previous studies have shown that the behavioral inhibition/activation systems (BIS/BAS) have substantial effects on substance use disorder and emotional disorders, and substance use disorder and emotional disorders often occur; in particular, females ...
Jinlan Xie +5 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Substance Use Disorder Treatment Confidentiality Boot Camp [PDF]
, 2017 [Excerpt]: INTRODUCTION: The Health Law and Policy Programs at UNH School of Law, Institute for Health Policy and Practice, and the NH Citizens Health Initiative have contracted with several of the New Hampshire Building Capacity for Transformation ...
Cameron, Stephanie +4 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Substance Use and Substance Use Disorders
Abstract This chapter reviews the DSM-5 definitions for substance use and other addictive disorders, their prevalence in the population, and known genetic, environmental, gene-environment, psychological, and social risk factors. It then examines how religion might influence the development and course of substance use disorders (SUDs ...
Harold G. Koenig +2 more
+5 more sources
Assessing Barriers to Mental Health Treatment [PDF]
, 2018 It has been well established that individuals with mental illness and substance use disorders face numerous barriers to accessing adequate health care treatment including inability to pay, lack of insurance coverage, lack of provider availability, and ...
Kilgus, Britta J
core +1 more source