FEBS Open Bio, EarlyView.Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal +2 more
wiley +1 more source
Integrated Treatment of Comorbid Depression and Substance Use Disorders [PDF]
, 2001 Dara A. Charney +2 more
openalex +1 more source
Is intimate partner violence more common in pregnant women with severe mental illness? A retrospective study [PDF]
, 2020 Objective: To examine the risk of past and current experiences of intimate partner violence (IPV) in women with severe mental illness (SMI) in pregnancy. Methods: We examined past and current experiences of IPV in women with SMI in pregnancy. The data of
Binns, Ray +4 more
core +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
Decoding the Narratives: Analyzing Personal Drug Experiences Shared on Reddit [PDF]
arXivOnline communities such as drug-related subreddits serve as safe spaces for people who use drugs (PWUD), fostering discussions on substance use experiences, harm reduction, and addiction recovery. Users' shared narratives on these forums provide insights into the likelihood of developing a substance use disorder (SUD) and recovery potential.
arxiv
The self‐perceived survival ability and reproductive fitness (SPFit) theory of substance use disorders [PDF]
, 2002 David B. Newlin
openalex +1 more source
Frontiers in PsychiatryBackgroundDespite the increasing substance use in Canada, our understanding of how substance use varies based on the intersections of gender, ethnicity/race, and income sources among preclinical populations remains limited.
Matiwos Soboka +7 more
doaj +1 more source
FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes
FEBS Open Bio, EarlyView.FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang +5 more
wiley +1 more source
Fairness in Computational Innovations: Identifying Bias in Substance Use Treatment Length of Stay Prediction Models with Policy Implications [PDF]
arXivPredictive machine learning (ML) models are computational innovations that can enhance medical decision-making, including aiding in determining optimal timing for discharging patients. However, societal biases can be encoded into such models, raising concerns about inadvertently affecting health outcomes for disadvantaged groups.
arxiv
Evidence-Based Treatments for Substance Use Disorders [PDF]
, 2003 Paul B. Gold, Kathleen T. Brady
openalex +1 more source