Results 51 to 60 of about 1,878,278 (369)
Individual differences in the neuropsychopathology of addiction. [PDF]
, 2017 Drug addiction or substance-use disorder is a chronically relapsing disorder that progresses through binge/intoxication, withdrawal/negative affect and preoccupation/anticipation stages.
George, Olivier, Koob, George F
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
COVID-19 and Mental Health/Substance Use Disorders on Reddit: A Longitudinal Study [PDF]
arXiv, 2020 COVID-19 pandemic has adversely and disproportionately impacted people suffering from mental health issues and substance use problems. This has been exacerbated by social isolation during the pandemic and the social stigma associated with mental health and substance use disorders, making people reluctant to share their struggles and seek help.
arxiv
Frontiers in Psychiatry, 2021 Previous studies have shown that the behavioral inhibition/activation systems (BIS/BAS) have substantial effects on substance use disorder and emotional disorders, and substance use disorder and emotional disorders often occur; in particular, females ...
Jinlan Xie +5 more
doaj +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Juvenile substance use and effects of substance use disorder on incarceration and grade retention in a sample referred for court clinic mental health evaluation [PDF]
, 2015 A significant amount of adolescents are involved in the drug court system. Within a few of the systems are mental health clinics providing more specific services to youth introduced into the courts.
Oliveira, Cassandra
core +1 more source
Epidemiology of substance use disorders [PDF]
Human Genetics, 2012 Epidemiological studies of substance use and substance use disorders (SUDs) have provided an abundance of data on the patterns of substance use in nationally representative samples across the world (Degenhardt et al. in PLoS Med 5(7):e141, 2008; Johnston et al.
Vetisha L. McClair +1 more
openaire +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Subnetwork hierarchies of biochemical pathways [PDF]
Bioinformatics 19, 532-538 (2003), 2002 We present a method to decompose biochemical networks into subnetworks based on the global geometry of the network. This method enables us to analyse the full hierarchical organisation of biochemical networks and is applied to 43 organisms from the WIT database.
arxiv +1 more source
Concerned parents, belligerent adolescent: Providing support to distressed parents
Indian Journal of Social Psychiatry, 2018 Societal changes have brought about transformation in the family dynamics in India. The youth of today is exposed to a wide variety of influences, and their tendency toward experimentation makes them vulnerable to get into unpleasant situations.
Siddharth Sarkar
doaj +1 more source