Results 101 to 110 of about 16,081,069 (297)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Prevalence of Substance Use and Associated Factors Among Secondary School Students in Marrakech Region, Morocco

Psychoactives
Adolescence is a phase characterized by reckless and risky behaviors, including the initiation and use of various illicit substances such as cannabis and alcohol.
Abdelmounaim Baslam, Samia Boussaa, Karima Raoui, Hamid Kabdy, Abdelfatah Aitbaba, Loubna El Yazouli, Rachida Aboufatima, Abderrahman Chait   +7 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Health Workers’ Perceptions of Suicide Risk Assessments: A Survey Study from Norway

Psychiatry International
Suicide is a serious and global health problem, with important consequences for individuals and for society. Understanding health workers’ perspectives is important for understanding how clinicians think about this topic and their attitudes toward and ...
Martin Bystad, Lars Lien, Sanja Krvavac, Rolf Wynn   +3 more
doaj   +1 more source

International quality standards for the treatment of comorbid substance use and mental health disorders.

Comorbid substance use and mental health disorders are highly prevalent and increase the risk of various adverse outcomes. Yet, treatment for comorbid substance use and mental health disorders is scattered and varies considerably between countries and ...
Ferri, Marica, Migchels, Charlotte
core   +1 more source

Canadian Institute for Substance Use Research Annual Report 2022-2023 [PDF]

, 2023
FacultyUnreviewe
Canadian Institute for Substance Use Research (CISUR)
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Substance use among young people in sub-Saharan Africa: a systematic review and meta-analysis

Frontiers in Psychiatry
BackgroundThe use of substances such as alcohol, tobacco, khat, or drugs among young people is becoming a public health concern globally, with particularly high prevalence rates in low and middle-income settings, where socio-cultural and economic factors
Jemal Ebrahim, Jemal Ebrahim, Jon Adams, Daniel Demant, Daniel Demant   +4 more
doaj   +1 more source

First-episode psychosis and co-occurring substance use disorders. [PDF]

, 2019
This US guide supports health care providers, systems, and communities to address first-episode psychosis and co-occurring substance use disorders.

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source