Results 101 to 110 of about 729,288 (289)

Personality disorders and substance use disorders: a narrative review

Electronic Physician, 2019
Background: Personality factors have always been considered to play an important role in the etiology of substance-related disorders. Psychopathologic factors underlying an individual's personality structure have a major role in his or her tendency to ...
Farhad Faridhosseini, Ali Saghebi, Mansoureh Mirzadeh   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Impact of comorbid psychiatric disorders on the outcome of substance abusers: a six year prospective follow-up in two Norwegian counties [PDF]

, 2006
Background Most help-seeking substance abusers have comorbid psychiatric disorders. The importance of such disorders for the long-term course of substance abuse is, however, still unclear.
Anne Signe Landheim, Kjell Bakken, Per Vaglum, RC Kessler, R Verheul, AS Landheim, TP Ellingstad, D Ciraulo, CE Grella, SR Rao, JB Ritsher, U Verthein, M Krausz, E Ravndal, A Øjehagen, GK Hulse, JB Ritsher, EE Hunter, B Haver, SA Gerdts, LN Robins, T Millon, LR Derogatis, HU Wittchen, P Flynn, JB Saunders, AH Berman, D Reinert, DW Hosmer, JW Finney, K Mann, F Guttinger, KK Schutte, Statistics Norway, S Lemke, T Noda, C Timko, G Vaillant, KM Schneider, PM Flynn, RL Hubbard, M Gossop, DD Simpson, DD Simpson, M Gossop, DD Satre, TJ Jarvis, HR Kranzler, E Nunes, G Gonzales, P Vaglum, R Secades-Villa   +51 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Gabapentin for Off-Label Use: Evidence-Based or Cause for Concern?

Substance Abuse: Research and Treatment, 2018
Gabapentin is widely used in the United States for a number of off-label indications, often as an alternative to opioid therapy. Increasing evidence has emerged suggesting that gabapentin may not be as benign as once thought and may be associated with ...
Alyssa M Peckham, Kirk E Evoy, Leslie Ochs, Jordan R Covvey   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Metabolic Syndrome and Associated Risk Factors in Norwegian Trauma-Exposed Inpatients: A Cross-Sectional Comparison with Blood Donors

Diabetes, Metabolic Syndrome and Obesity
Grethe Emilie Roer,1,2 Ingeborg Bolstad,3 Dawit Shawel Abebe,1,2 Jan Aaseth,3,4 Morten Haugen,5,6 Lars Lien1,3 1Research Center for Substance Use Disorders and Mental Illness, Innlandet Hospital Trust, Brumunddal, NO-2381, Norway; 2Department of Nursing ...
Roer GE, Bolstad I, Abebe DS, Aaseth J, Haugen M, Lien L   +5 more
doaj  

Mental health and energy drink consumption among Norwegian adolescents; a cross-sectional study

BMC Public Health
Background Energy drinks (ED) are marketed as boosters of mental and physical health, but few studies have looked at the mental health of adolescents who consume large amounts of ED.
Siri Kaldenbach, Marja Leonhardt, Tor A. Strand, Mads Holten-Andersen   +3 more
doaj   +1 more source

Prevalence of Substance Use and Associated Factors Among Secondary School Students in Marrakech Region, Morocco

Psychoactives
Adolescence is a phase characterized by reckless and risky behaviors, including the initiation and use of various illicit substances such as cannabis and alcohol.
Abdelmounaim Baslam, Samia Boussaa, Karima Raoui, Hamid Kabdy, Abdelfatah Aitbaba, Loubna El Yazouli, Rachida Aboufatima, Abderrahman Chait   +7 more
doaj   +1 more source

Continuing care groups: long term treatment of substance use disorders [PDF]

, 2014
Master's Project (M.Ed.) University of Alaska Fairbanks, 2014Substance use disorders are chronic diseases that affect individuals, families, and communities. These illnesses frequently require several courses of treatment to achieve abstinence. Inpatient
Foote, Olivia
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