Results 81 to 90 of about 729,288 (289)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Models of Concurrent Disorder Service: Policy, Coordination, and Access to Care

Frontiers in Psychiatry, 2019
Background: Societal capacity to address the service needs of persons with concurrent mental health and substance-use disorders has historically been challenging given a traditionally siloed approach to mental health and substance-use care.
Mary Wiktorowicz, Aber Abdulle, Kaitlin Di Pierdomenico, Sheila A. Boamah   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Patterns of management of patients with dual disorder (psychosis) in Italy: a survey of psychiatrists and other physicians focusing on clinical practice [PDF]

, 2018
© 2018 Clerici, de Bartolomeis, De Filippis, Ducci, Maremmani, Martinotti and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Patients with severe psychotic disorders such as ...
Acquas, Akiskal, Archie, Bacopoulos, Blum, Blum, Bowirrat, Carra, Connelly, Cuomo, De Bartolomeis, De Bartolomeis, Degenhardt, Delisi, Fantini, Fiorillo, Getzen, Gouzoulis-Mayfrank, Grob, Hertzog, Howes, Iasevoli, Kerner, Lambert, Maremmani, Martin, Martinotti, Nesvag, Ostuzzi, Papageorgiou, Regier, Roncero, Rovai, Rubino, Samaha, Samalin, Sugawara, Szkultecka-Debek, Ventriglio, Volkow   +39 more
core   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Knowledge of and Attitude on Assessment of Substance Use disorders of Nurses Working in General Wards

Indian Journal of Psychiatric Nursing, 2018
Early detection of substance abuse disorders can facilitate treatment. Health care professional's knowledge and attitudes can play a role in the failure to identify and address patients with substance use problems and may negatively influence the care ...
Sumity Arora Tarafdar, Sandhya Gupta
doaj   +1 more source

Opinion: The Mental Health Parity and Addiction Equity Act: What Parity Means For New Hampshire [PDF]

, 2017
[Excerpt] New Hampshire lawyers can help clients and colleagues with mental health or substance use disorders by advising individuals how to overcome barriers to insurance coverage for treatment, and encouraging them to pursue state and federally ...
Hodder, Lucy C.
core   +1 more source

Alexithymia in young adults with substance use disorders: Critical issues about specificity and treatment predictivity [PDF]

, 2018
Several studies have reported high rates of alexithymia in drug-dependent individuals, but supporting evidence attests association between alexithymia and a variety of psychiatric disorders, raising doubts about its specificity.
DE CARLI, Pietro, Gatta, Michela, Miscioscia, Marina, Parolin, Micol, Patrizia, Cristofalo, Simonelli, Alessandra   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

‘They really want to find some kind of box they can put you in’: how young people with severe mental health problems and complex needs talk about their past treatment in traditional child and adolescent mental health services - a critical discourse analysis

Frontiers in Psychiatry
Challenges in child and adolescent mental health services (CAMHS), including complex and fragmented services, are well documented, particularly to young people with severe mental health problems and complex needs.
Marthe Johansen, Ottar Ness, Hanne Kilen Stuen, Eva Brekke, Eva Brekke, Anne Landheim, Anne Landheim   +6 more
doaj   +1 more source