Results 61 to 70 of about 321,265 (263)

Knowledge of and Attitude on Assessment of Substance Use disorders of Nurses Working in General Wards

Indian Journal of Psychiatric Nursing, 2018
Early detection of substance abuse disorders can facilitate treatment. Health care professional's knowledge and attitudes can play a role in the failure to identify and address patients with substance use problems and may negatively influence the care ...
Sumity Arora Tarafdar, Sandhya Gupta
doaj   +1 more source

Caffeine and Substance Use Disorders [PDF]

Journal of Caffeine Research, 2013
Caffeine is the most consumed psychoactive drug in the world. As a psychostimulant, it shows all the pharmacological properties of classical psychostimulants, such as cocaine and amphetamine. Those properties include arousal, motor activation, and reinforcing effects.
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

‘They really want to find some kind of box they can put you in’: how young people with severe mental health problems and complex needs talk about their past treatment in traditional child and adolescent mental health services - a critical discourse analysis

Frontiers in Psychiatry
Challenges in child and adolescent mental health services (CAMHS), including complex and fragmented services, are well documented, particularly to young people with severe mental health problems and complex needs.
Marthe Johansen, Ottar Ness, Hanne Kilen Stuen, Eva Brekke, Eva Brekke, Anne Landheim, Anne Landheim   +6 more
doaj   +1 more source

HIV and Substance Use Disorders

Infectious Disease Clinics of North America
Over 1.2 million Americans aged 13 years and older have been diagnosed with human immunodeficiency virus (HIV). While HIV incidence has been declining since 2017, the risk of HIV acquisition and transmission persists among persons who use drugs via injection drug use and unprotected sexual intercourse associated with substance use.
Lier, Audun J., Tarfa, Adati, Shenoi, Sheela V., Kuo, Irene, Springer, Sandra A.   +4 more
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Personality disorders and substance use disorders: a narrative review

Electronic Physician, 2019
Background: Personality factors have always been considered to play an important role in the etiology of substance-related disorders. Psychopathologic factors underlying an individual's personality structure have a major role in his or her tendency to ...
Farhad Faridhosseini, Ali Saghebi, Mansoureh Mirzadeh   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source